Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Retinal vessel diameters during hyperglycemia
研究概览
简要总结
The aim of the study is to investigate how the retina adapts to different metabolic challenges, e.g. chronic systemic hypoxia, hyperglycemia, special training conditions or diets as well as transient changes in the content of oxygen and glucose in the blood.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals
- •Inclusion Criteria:
- •Healthy volunteers.
- •No known systemic or ocular disease.
排除标准
- •Any systemic or ocular disease.
- •Patients with diabetes
- •Inclusion criteria:
- •Diabetes mellitus
- •No intraocular disease other than conditions attributable to diabetes.
- •Exclusion criteria:
- •Intraocular disease other than conditions attributable to diabetes.
- •Systemic conditions which might contraindicate hyperoxic stimulation.
研究组 & 干预措施
Healthy
Healthy study participanats
干预措施: Hyperoxia (Other)
Diabetes
Patients with diabetes
干预措施: Hyperoxia (Other)
Healthy
Healthy study participanats
干预措施: Glucose (Other)
Diabetes
Patients with diabetes
干预措施: Glucose (Other)
结局指标
主要结局
Retinal vessel diameters during hyperglycemia
时间窗: Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load
Measurement of retinal vessel diameters before, during and after hyperglycemic stimulation.
Retinal perfusion during hyperglycemia
时间窗: Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load
Measurement of retinal perfusion velocities before, during and after hyperglycemic stimulation.
Retinal oximetry during hyperglycemia
时间窗: Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load
Measurement of retinal oximetry status before, during and after hyperglycemic stimulation.
Retinal vessel diameters during hyperoxia
时间窗: Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia
Measurement of retinal vessel diameters before, during and after hyperoxic stimulation.
Retinal perfusion velocities during hyperoxia
时间窗: Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia
Measurement of retinal perfusion velocities before, during and after hyperoxic stimulation.
Retinal oximetry during hyperoxia
时间窗: Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia
Measurement of retinal oximetry status before, during and after hyperoxic stimulation.
次要结局
未报告次要终点
研究者
Oliver Niels Klefter
MD
Glostrup University Hospital, Copenhagen