Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.
- Conditions
- Gastric CancerGastroesophageal Junction Adenocarcinoma
- Interventions
- Registration Number
- NCT05111626
- Lead Sponsor
- Amgen
- Brief Summary
The main objective of Part 1 is to evaluate the safety and tolerability of bemarituzumab plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) and nivolumab.
The main objective Part 2 is to compare efficacy of bemarituzumab plus chemotherapy (mFOLFOX6 or capecitabine combined with oxaliplatin (CAPOX)) and nivolumab to placebo plus chemotherapy (mFOLFOX6 or CAPOX) and nivolumab as assessed by overall survival.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 507
Not provided
- Prior treatment with any selective inhibitor of the fibroblast growth factor (FGF)-FGFR pathway
- Known positive human epidermal growth factor receptor 2 (HER2) status
- Untreated or symptomatic central nervous system disease metastases and leptomeningeal disease
- Peripheral sensory neuropathy grade 2 or higher
- Clinically significant cardiac disease
- Other malignancy within the last 2 years (exceptions for definitively treated disease)
- Chronic or systemic ophthalmologic disorders
- Major surgery or other investigational study within 28 days prior to randomization
- Palliative radiotherapy within 14 days prior to randomization
- Abnormalities of the cornea that may pose an increased risk of developing a corneal ulcer
- Active autoimmune disease that has required systemic treatment (except replacement therapy) within the past 2 years or any other diseases requiring immunosuppressive therapy while on study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Part 1 Safety Lead-in: Bemarituzumab with mFOLFOX6 and Nivolumab Bemarituzumab Participants will be administered bemarituzumab at different doses with mFOLFOX6 and nivolumab to determine the recommended phase 3 dose (RP3D) based on occurrence of dose-limiting toxicities (DLTs), and on an evaluation of the overall safety, tolerability, and pharmacokinetics (PK). Part 1 Safety Lead-in: Bemarituzumab with mFOLFOX6 and Nivolumab Nivolumab Participants will be administered bemarituzumab at different doses with mFOLFOX6 and nivolumab to determine the recommended phase 3 dose (RP3D) based on occurrence of dose-limiting toxicities (DLTs), and on an evaluation of the overall safety, tolerability, and pharmacokinetics (PK). Part 1 Safety Lead-in: Bemarituzumab with mFOLFOX6 and Nivolumab Chemotherapy Participants will be administered bemarituzumab at different doses with mFOLFOX6 and nivolumab to determine the recommended phase 3 dose (RP3D) based on occurrence of dose-limiting toxicities (DLTs), and on an evaluation of the overall safety, tolerability, and pharmacokinetics (PK). Part 2: Bemarituzumab with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Bemarituzumab Participants will be administered bemarituzumab at the RP3D determined from Part 1 in combination with mFOLFOX6 and nivolumab on a 14-day cycle. Or participants will be administered bemarituzumab in combination with CAPOX and nivolumab on a 21-day cycle. Part 2: Bemarituzumab with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Nivolumab Participants will be administered bemarituzumab at the RP3D determined from Part 1 in combination with mFOLFOX6 and nivolumab on a 14-day cycle. Or participants will be administered bemarituzumab in combination with CAPOX and nivolumab on a 21-day cycle. Part 2: Bemarituzumab with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Chemotherapy Participants will be administered bemarituzumab at the RP3D determined from Part 1 in combination with mFOLFOX6 and nivolumab on a 14-day cycle. Or participants will be administered bemarituzumab in combination with CAPOX and nivolumab on a 21-day cycle. Part 2: Placebo with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Nivolumab Participants will be administered placebo comparator in combination with mFOLFOX6 and nivolumab on a 14-day cycle. Or participants will be administered placebo comparator in combination with CAPOX and nivolumab on a 21-day cycle. Part 2: Placebo with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Placebo Participants will be administered placebo comparator in combination with mFOLFOX6 and nivolumab on a 14-day cycle. Or participants will be administered placebo comparator in combination with CAPOX and nivolumab on a 21-day cycle. Part 2: Placebo with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Chemotherapy Participants will be administered placebo comparator in combination with mFOLFOX6 and nivolumab on a 14-day cycle. Or participants will be administered placebo comparator in combination with CAPOX and nivolumab on a 21-day cycle.
- Primary Outcome Measures
Name Time Method Part 1: Number of Participants With Clinically Significant Changes in Vital Signs Up to 4.5 years Part 1: Number of Participants With Clinically Significant Changes in Visual Acuity Up to 4.5 years Part 1: Number of Participants With Clinically Significant Changes in Physical Examinations Up to 4.5 years Part 1: Number of Participants with Clinically Significant Changes in Clinical Laboratory Tests Up to 4.5 years Part 2: Overall Survival in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 1: Number of Participants Who Experienced One or More Related TEAEs Up to 4.5 years Part 1: Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAEs) Up to 4.5 years Part 1: Number of Participants Who Experienced DLTs 28 days
- Secondary Outcome Measures
Name Time Method Part 2: Change From Baseline in EORTC QLQ-C30 Individual Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Baseline to up to 4.5 years Part 1: Objective Response (OR) Up to 4.5 years Part 1: Duration of Response (DoR) Up to 4.5 years Part 1: Disease Control Rate (DCR) Up to 4.5 years Part 1: Progression Free Survival (PFS) Up to 4.5 years Part 1: Overall Survival Up to 4.5 years Part 1: Maximum Observed Concentration (Cmax) of Bemarituzumab Day 1 to up to 4.5 years Part 1: Area Under the Concentration Time Curve (AUC) of Bemarituzumab Day 1 to up to 4.5 years Part 1: Observed Concentration at the End of a Dose Interval (Ctrough) of Bemarituzumab Day 1 to up to 4.5 years Part 1: Number of Participants With Anti-Bemarituzumab Antibody Formation Day 1 to up to 4.5 years Part 2: PFS in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: OR in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: Number of Participants Who Experienced One or More TEAEs Up to 4.5 years Part 2: Number of Participants With Clinically Significant Changes in Vital Signs Up to 4.5 years Part 2: Number of Participants With Clinically Significant Changes in Visual Acuity Up to 4.5 years Part 2: Number of Participants with Clinically Significant Changes in Clinical Laboratory Tests Up to 4.5 years Part 2: Overall Survival in All Randomized Participants Up to 4.5 years Part 2: PFS in All Randomized Participants Up to 4.5 years Part 2: Objective Response Rate (ORR) in All Randomized Participants Up to 4.5 years Part 2: DoR in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: DCR in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: Mean Score in European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Version 3.0 (QLQ-C30) Individual Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: Mean Score in Stomach Cancer Related Symptoms Measured by EORTC Quality of Life Questionnaire-Stomach 22 (QLQ-STO22) in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: Change From Baseline in Stomach Cancer Related Symptoms Measured by EORTC QLQ-STO22 in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Baseline to up to 4.5 years Part 2: Mean Score of Visual Analogue Scale (VAS) Scores as Measured by EuroQol 5-dimensional (EQ-5D-5L) in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Up to 4.5 years Part 2: Change From Baseline of VAS Scores as Measured by EQ-5D-5L in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Baseline to up to 4.5 years Part 2: Time to Deterioration in Stomach Cancer Related Symptoms Measured by EORTC QLQ-STO22 in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Day 1 to up to 4.5 years Part 2: Time to Deterioration in Health-Related Quality of Life (HRQoL) Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Day 1 to up to 4.5 years Part 2: Time to Deterioration in Physical Function Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants Day 1 to up to 4.5 years Part 2: Cmax of Bemarituzumab Day 1 to up to 4.5 years Part 2: Ctrough of Bemarituzumab Day 1 to up to 4.5 years Part 2: Number of Participants With Anti-Bemarituzumab Antibody Formation Day 1 to up to 4.5 years
Trial Locations
- Locations (350)
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
University of Illinois Chicago
🇺🇸Chicago, Illinois, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Liaoning Cancer Hospital
🇨🇳Shenyang, Liaoning, China
Istituto Nazionale dei Tumori IRCCS Fondazione Giovanni Pascale
🇮🇹Napoli, Italy
The Oncology Institute Clinical Research
🇺🇸Cerritos, California, United States
City of Hope National Medical Center
🇺🇸Duarte, California, United States
Presbyterian Intercommunity Hospital Health Whitter Hospital
🇺🇸Whittier, California, United States
Summit Medical Group
🇺🇸Florham Park, New Jersey, United States
Gabrail Cancer Center, LLC
🇺🇸Canton, Ohio, United States
Saint Lukes University Health Network
🇺🇸Allentown, Pennsylvania, United States
West Cancer Center
🇺🇸Germantown, Tennessee, United States
Virginia Oncology Associates
🇺🇸Norfolk, Virginia, United States
United States Oncology Regulatory Affairs Corporate Office
🇺🇸The Woodlands, Texas, United States
Northwest Cancer Specialists - Vancouver
🇺🇸Vancouver, Washington, United States
Aurora Health Care Metro Inc
🇺🇸Milwaukee, Wisconsin, United States
Fundacion Ars Medica
🇦🇷San Salvador de Jujuy, Jujuy, Argentina
Ballarat Health Services
🇦🇺Ballarat, Victoria, Australia
Medizinische Universitaet Graz
🇦🇹Graz, Austria
Medizinische Universitaet Innsbruck
🇦🇹Innsbruck, Austria
Landeskrankenhaus Feldkirch
🇦🇹Rankweil, Austria
Krankenhaus Wiener Neustadt
🇦🇹Wiener Neustadt, Austria
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
🇧🇪Bruxelles, Belgium
Universitaetsklinikum Allgemeines Krankenhaus Wien
🇦🇹Wien, Austria
Universitair Ziekenhuis Brussel
🇧🇪Jette, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
🇧🇪Leuven, Belgium
Algemeen Ziekenhuis Turnhout Campus Sint-Jozef
🇧🇪Turnhout, Belgium
Hospital Haroldo Juacaba - Instituto do Cancer do Ceara
🇧🇷Fortaleza, Ceará, Brazil
Hospital Sirio Libanes
🇧🇷Brasilia, Distrito Federal, Brazil
Personal Oncologia de Precisao e Personalizada
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Hospital Evangelico de Cachoeiro de Itapemirim
🇧🇷Cachoeiro de Itapemirim, Espírito Santo, Brazil
Liga Norte-Riograndense Contra O Cancer
🇧🇷Natal, Rio Grande Do Norte, Brazil
Fundacao Antonio Prudente AC Camargo Cancer Center
🇧🇷Sao Paulo, São Paulo, Brazil
Instituto Coi
🇧🇷Rio de Janeiro, Brazil
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD
🇧🇬Haskovo, Bulgaria
Multiprofile Hospital for Active Treatment Central Onco Hospital OOD
🇧🇬Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment - Uni Hospital OOD
🇧🇬Panagyurishte, Bulgaria
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Oncocentro Apys
🇨🇱Viña del Mar, Valparaíso, Chile
CHU de Quebec Hopital de l Enfant Jesus
🇨🇦Quebec, Canada
Centro De Estudios Clínicos Suecia SpA
🇨🇱Santiago de Chile, Santiago, Chile
IC La Serena Research
🇨🇱La Serena, Chile
Oncovida
🇨🇱Santiago, Chile
Icegclinic
🇨🇱Santiago, Chile
Centro de Estudios Clinicos e Investigaciones Medicas CeCim
🇨🇱Santiago, Chile
The First Affiliated Hospital of Anhui Medical University
🇨🇳Hefei, Anhui, China
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
🇨🇳Beijing, Beijing, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China
Lanzhou University Second Hospital
🇨🇳Lanzhou, Gansu, China
Gansu Provincial Cancer Hospital
🇨🇳Lanzhou, Gansu, China
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Guangdong Provincial Peoples Hospital
🇨🇳Guangzhou, Guangdong, China
Gansu Wuwei Tumour Hospital
🇨🇳Wuwei, Gansu, China
The first people's Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Cancer Hospital of Shantou University Medical College
🇨🇳Shantou, Guangdong, China
Guangxi Medical University Cancer Hospital
🇨🇳Nanning, Guangxi, China
The First Affiliated Hospital of Hainan Medical University
🇨🇳Haikou, Hainan, China
Fourth Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
The First Affiliated Hospital of Henan University of science and Technology
🇨🇳Luoyang, Henan, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
Taihe Hospital Affiliated Hospital of Hubei University of Medicine
🇨🇳Shiyan, Hubei, China
Tongji Hospital Tongji Medical College Of Hust
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South Universiy
🇨🇳Changsha, Hunan, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Inner Mongolia Autonomous Region Peoples Hospital
🇨🇳Hohhot, Inner Mongolia, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, Jiangsu, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Affiliated Hospital of Jiangnan University
🇨🇳Wuxi, Jiangsu, China
The First People's Hospital of Changzhou
🇨🇳Changzhou, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical University
🇨🇳Xuzhou, Jiangsu, China
Affiliated Hospital of Yangzhou University
🇨🇳Yangzhou, Jiangsu, China
Northern Jiangsu Peoples Hospital
🇨🇳Yangzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
The First Bethune Hospital of Jilin University
🇨🇳Changchun, Jilin, China
China-Japan Union Hospital of Jilin University
🇨🇳Changchun, Jilin, China
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China
The First Affiliated Hospital of Xian Jiaotong University
🇨🇳Xian, Shaanxi, China
Shaanxi Provincial Peoples Hospital
🇨🇳Xian, Shaanxi, China
Qilu Hospital of Shandong University
🇨🇳Jinan, Shandong, China
The Affiliated Cancer Hospital of Shandong First Medical University
🇨🇳Jinan, Shandong, China
Affiliated Hospital of Jining Medical University
🇨🇳Jining, Shandong, China
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, Shanghai, China
The Affiliated Hospital of Qingdao University
🇨🇳Qingdao, Shandong, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Shanghai East Hospital
🇨🇳Shanghai, Shanghai, China
Changzhi Peoples Hospital
🇨🇳Changzhi, Shanxi, China
Linfen Central Hospital
🇨🇳Linfen, Shanxi, China
Sichuan Cancer Hospital
🇨🇳Chengdu, Sichuan, China
West China Hospital of Sichuan University
🇨🇳Chengdu, Sichuan, China
The Affiliated Hospital of Southwest Medical University
🇨🇳Luzhou, Sichuan, China
Tianjin Medical University Cancer institute and hospital
🇨🇳Tianjin, Tianjin, China
The First Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Yunnan Cancer Hospital
🇨🇳Kunming, Yunnan, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province
🇨🇳Linhai, Zhejiang, China
Lishui Municipal central Hospital
🇨🇳Lishui, Zhejiang, China
The First Affiliate Hospital of Ningbo University
🇨🇳Ningbo, Zhejiang, China
Hospital Pablo Tobon Uribe
🇨🇴Medellin, Antioquia, Colombia
Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA
🇨🇴Rionegro, Antioquia, Colombia
Sociedad de Oncologia y Hematologia del Cesar
🇨🇴Valledupar, Cesar, Colombia
Fundacion Cardiovascular de Colombia
🇨🇴Bucaramanga, Santander, Colombia
Fundacion Oftalmologica de Santander - Foscal
🇨🇴Floridablanca, Santander, Colombia
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Fakultni Thomayerova nemocnice
🇨🇿Praha 4, Czechia
Centre Hospitalier Universitaire Amiens Picardie - Hopital Sud
🇫🇷Amiens Cedex 1, France
Centre Hospitalier Regional Universitaire de Besancon, Hopital Jean Minjoz
🇫🇷Besançon, France
Institut Bergonie
🇫🇷Bordeaux, France
Centre Hospitalier Universitaire de Brest - Cavale Blanche
🇫🇷Brest Cedex, France
Centre Hospitalier Universitaire de Clermont Ferrand, Hopital Estaing
🇫🇷Clermont-Ferrand cedex 1, France
Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez
🇫🇷Lille, France
Centre Hospitalier Universitaire de Limoges - Hopital Dupuytren
🇫🇷Limoges Cedex, France
Klinikum der LMU Muenchen
🇩🇪Muenchen, Germany
Hopital Europeen Georges Pompidou
🇫🇷Paris, France
Centre Leon Berard
🇫🇷Lyon cedex 8, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Hopital Saint Louis
🇫🇷Paris Cedex 10, France
Institut Mutualiste Montsouris
🇫🇷Paris Cedex 14, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
🇫🇷Rennes Cedex 9, France
Centre Hospitalier Universitaire de Rouen
🇫🇷Rouen Cedex, France
Centre Rene Gauducheau - Institut de Cancerologie de l Ouest
🇫🇷Saint Herblain, France
Centre Hospitalier Universitaire Nord de Saint Etienne - Hopital Nord
🇫🇷Saint Priest en Jarez, France
Institut de cancerologie Strasbourg Europe
🇫🇷Strasbourg cedex, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
🇫🇷Toulouse Cedex 9, France
Charite - Universitaetsmedizin Berlin, Campus Virchow
🇩🇪Berlin, Germany
Institut Gustave Roussy
🇫🇷Villejuif, France
Universitaetsklinikum Dresden
🇩🇪Dresden, Germany
Haematologisch Onkologische Praxis Eppendorf
🇩🇪Hamburg, Germany
Krankenhaus Nordwest GmbH
🇩🇪Frankfurt am Main, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitaetsklinikum Schleswig-Holstein
🇩🇪Kiel, Germany
Universitaetsklinikum Leipzig
🇩🇪Leipzig, Germany
Regional Kliniken Holding Klinikum Ludwigsburg
🇩🇪Ludwigsburg, Germany
Johannes Gutenberg Universitaet Mainz
🇩🇪Mainz, Germany
Universitaetsmedizin Mannheim
🇩🇪Mannheim, Germany
Klinikum rechts der Isar der TUM
🇩🇪Muenchen, Germany
Universitaetsklinikum der Eberhard Karls Universitaet Tuebingen
🇩🇪Tuebingen, Germany
Universitaetsklinikum Ulm
🇩🇪Ulm, Germany
Klinikum der Stadt Wolfsburg
🇩🇪Wolfsburg, Germany
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
🇭🇺Budapest, Hungary
Orszagos Onkologiai Intezet
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
🇭🇺Nyiregyhaza, Hungary
Tolna Varmegyei Balassa Janos Korhaz
🇭🇺Szekszard, Hungary
Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet
🇭🇺Szolnok, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
🇭🇺Tatabanya, Hungary
Rambam Health Care Campus
🇮🇱Haifa, Israel
Hadassah Ein-Kerem Medical Center
🇮🇱Jerusalem, Israel
Sheba Medical Center
🇮🇱Ramat Gan, Israel
Tel-Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona
🇮🇹Ancona, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
🇮🇹Bergamo, Italy
Istituto Ospedaliero Fondazione Poliambulanza
🇮🇹Brescia, Italy
Ente Ospedaliero IRCCS Saverio De Bellis
🇮🇹Castellana Grotte, Italy
Azienda Socio Sanitaria Territoriale di Cremona
🇮🇹Cremona, Italy
Azienda Ospedaliero Universitaria Careggi
🇮🇹Firenze, Italy
Ospedale Policlinico San Martino IRCCS
🇮🇹Genova, Italy
IRCCS Ospedale San Raffaele
🇮🇹Milano, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
🇮🇹Milano, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
🇮🇹Milano, Italy
Azienda Ospedaliero Universitaria Luigi Vanvitelli
🇮🇹Napoli, Italy
Istituto Oncologico Veneto IRCCS
🇮🇹Padova, Italy
Azienda Ospedaliera Universitaria Pisana
🇮🇹Pisa, Italy
Nagoya University Hospital
🇯🇵Nagoya-shi, Aichi, Japan
Chiba Cancer Center
🇯🇵Chiba-shi, Chiba, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa-shi, Chiba, Japan
National Hospital Organization Shikoku Cancer Center
🇯🇵Matsuyama-shi, Ehime, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-shi, Fukuoka, Japan
Gifu University Hospital
🇯🇵Gifu-shi, Gifu, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Hyogo Cancer Center
🇯🇵Akashi-shi, Hyogo, Japan
Yokohama City University Medical Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Kobe City Medical Center General Hospital
🇯🇵Kobe-shi, Hyogo, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata-shi, Niigata, Japan
Kansai Medical University Hospital
🇯🇵Hirakata-shi, Osaka, Japan
Osaka International Cancer Institute
🇯🇵Osaka-shi, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka, Japan
Osaka University Hospital
🇯🇵Suita-shi, Osaka, Japan
Saitama Cancer Center
🇯🇵Kitaadachi-gun, Saitama, Japan
Shizuoka Cancer Center
🇯🇵Sunto-gun, Shizuoka, Japan
National Cancer Center Hospital
🇯🇵Chuo-ku, Tokyo, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
🇯🇵Koto-ku, Tokyo, Japan
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Republic of
Jeonbuk National University Hospital
🇰🇷Jeonju-si, Jeollabuk-do, Korea, Republic of
National Cancer Center
🇰🇷Goyang-si Gyeonggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Beskidzkie Centrum Onkologii Szpital Miejski imienia Jana Pawla Drugiego
🇵🇱Bielsko-Biala, Poland
Narodowy Instytut Onkologii im M Sklodowskiej-Curie Panstwowy Instytut Badawczy Oddzial w Gliwicach
🇵🇱Gliwice, Poland
Przychodnia Lekarska Komed Roman Karaszewski
🇵🇱Konin, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1
🇵🇱Lublin, Poland
Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji
🇵🇱Olsztyn, Poland
Mazowiecki Szpital Wojewodzki im Sw Jana Pawla II w Siedlcach spzoo
🇵🇱Siedlce, Poland
Centrum Medyczne Pratia Poznan
🇵🇱Skorzewo, Poland
Uniwersytecki Szpital Kliniczny nr 1 im prof Tadeusza Sokolowskiego Pum w Szczecinie
🇵🇱Szczecin, Poland
Lux med onkologia sp zoo szpital szamocka
🇵🇱Warszawa, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
🇵🇱Warszawa, Poland
Mtz Clinical Research powered by Pratia
🇵🇱Warszawa, Poland
Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu
🇵🇱Wroclaw, Poland
Unidade Local de Saude de Braga, EPE
🇵🇹Braga, Portugal
Unidade Local de Saude do Alto Ave, EPE
🇵🇹Guimaraes, Portugal
Hospital da Luz, SA
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
🇵🇹Matosinhos, Portugal
Hospital Cuf porto
🇵🇹Porto, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
🇵🇹Porto, Portugal
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao
🇵🇹Porto, Portugal
Institutul Clinic Fundeni
🇷🇴Bucharest, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca
🇷🇴Cluj Napoca, Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof Dr Octavian Fodor
🇷🇴Cluj-Napoca, Romania
Centrul de Oncologie Sf Nectarie SRL
🇷🇴Craiova, Romania
Institutul Regional de Oncologie Iasi
🇷🇴Iasi, Romania
Spitalul Municipal Ploiesti
🇷🇴Ploiesti, Romania
SC Oncomed SRL
🇷🇴Timisoara, Romania
National University Hospital
🇸🇬Singapore, Singapore
National Cancer Centre Singapore
🇸🇬Singapore, Singapore
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Andalucía, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Asturias, Spain
Hospital del Mar
🇪🇸Barcelona, Cataluña, Spain
Hospital Universitari Vall d Hebron
🇪🇸Barcelona, Cataluña, Spain
Hospital Clinic i Provincial de Barcelona
🇪🇸Barcelona, Cataluña, Spain
Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals
🇪🇸Hospitalet de Llobregat, Cataluña, Spain
Hospital General Universitario de Elche
🇪🇸Elche, Comunidad Valenciana, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Comunidad Valenciana, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Comunidad Valenciana, Spain
Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera
🇪🇸A Coruña, Galicia, Spain
Hospital Universitario de Navarra
🇪🇸Pamplona, Navarra, Spain
Universitaetsspital Basel
🇨🇭Basel, Switzerland
Inselspital Bern
🇨🇭Bern, Switzerland
Kantonsspital Graubuenden
🇨🇭Chur, Switzerland
Hopitaux Universitaires de Geneve
🇨🇭Geneve, Switzerland
Universitaetsspital Zuerich
🇨🇭Zuerich, Switzerland
Onkozentrum Zuerich
🇨🇭Zurich, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Siriraj Hospital
🇹🇭Bangkok, Thailand
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
🇨🇳Taoyuan, Taiwan
Chulabhorn Hospital
🇹🇭Bangkok, Thailand
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Chiangrai Prachanukroh Hospital
🇹🇭Chiang Rai, Thailand
Ninewells Hospital and Medical School
🇬🇧Dundee, United Kingdom
Christie Hospital
🇬🇧Manchester, United Kingdom
Royal Free Hospital
🇬🇧London, United Kingdom
Prince of Songkla Hospital
🇹🇭Songkhla, Thailand
Addenbrookes Hospital
🇬🇧Cambridge, United Kingdom
University Hospital Coventry
🇬🇧Coventry, United Kingdom
Mount Vernon Cancer Centre
🇬🇧Northwood, United Kingdom
Churchill Hospital
🇬🇧Oxford, United Kingdom
Southampton General Hospital
🇬🇧Southampton, United Kingdom
Torbay Hospital
🇬🇧Torquay, United Kingdom
Translational Research in Oncology - US Inc
🇺🇸Santa Monica, California, United States
Translational Research in Oncology US Inc, Trio Central Pharmacy
🇺🇸Santa Monica, California, United States
Stony Brook University Medical Center
🇺🇸Stony Brook, New York, United States
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital General Universitario Gregorio Maranon
🇪🇸Madrid, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
US Oncology Research Investigational Products Center
🇺🇸The Woodlands, Texas, United States
Yale New Haven Hospital Yale Cancer Center
🇺🇸New Haven, Connecticut, United States
Adventist Health System/Sunbelt, Inc d/b/a AdventHealth Orlando
🇺🇸Orlando, Florida, United States
Orlando Health Cancer Institute
🇺🇸Orlando, Florida, United States
Texas Oncology - Austin Midtown
🇺🇸Austin, Texas, United States
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Guys Hospital
🇬🇧London, United Kingdom
Zhongshan Hospital Fudan University
🇨🇳Shanghai, Shanghai, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Princess Margaret Cancer Centre
🇨🇦Toronto, Ontario, Canada
Centre Hospitalier de L Universite de Montreal
🇨🇦Montréal, Quebec, Canada
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Grampians Health
🇦🇺Ballarat, Victoria, Australia
Texas Oncology Central-South
🇺🇸Austin, Texas, United States
Chinese University of Hong Kong, Prince of Wales Hospital
🇭🇰Shatin, New Territories, Hong Kong
Providence Cancer Institute Franz Clinic
🇺🇸Portland, Oregon, United States
Florida Cancer Specialists - Fort Myers
🇺🇸Fort Myers, Florida, United States
Fujian Cancer Hospital
🇨🇳Fuzhou, Fujian, China
Hopital De Libramont
🇧🇪Libramont, Belgium
Hospital das Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Fundacao Pio 12 Hospital de Amor de Barretos
🇧🇷Barretos, São Paulo, Brazil
Instituto do Cancer Arnaldo Vieira de Carvalho
🇧🇷Sao Paulo, São Paulo, Brazil
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
🇧🇷Sao Paulo, São Paulo, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
🇧🇷São José do Rio Preto, São Paulo, Brazil
Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp
🇧🇷São Paulo, Brazil
Complex Oncology Center - Burgas
🇧🇬Burgas, Bulgaria
Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia
🇧🇬Sofia, Bulgaria
Multiprofile Hospital for Active Treatment Serdika EOOD
🇧🇬Sofia, Bulgaria
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Sunnybrook Research Institute Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
The First Affiliated Hospital of Bengbu Medical University
🇨🇳Bengbu, Anhui, China
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
Cancer and Blood Specialty Clinic
🇺🇸Downey, California, United States
Torrance Memorial Physician Network
🇺🇸Redondo Beach, California, United States
University of California Los Angeles
🇺🇸Los Angeles, California, United States
Olive View-University of California in Los Angeles Medical Center
🇺🇸Sylmar, California, United States
Sarah Cannon Research Institute
🇺🇸Nashville, Tennessee, United States
Hospital Provincial del Centenario
🇦🇷Rosario, Santa Fe, Argentina
Landeskrankenhaus Salzburg
🇦🇹Salzburg, Austria
Institut Jules Bordet
🇧🇪Brussels, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
🇧🇪Liege, Belgium
Centro de Estudios Clinicos SAGA Spa
🇨🇱Santiago, Chile
Anhui Provincial Cancer Hospital
🇨🇳Hefei, Anhui, China
Cancer Hospital of Chinese Academy of Medical Sciences
🇨🇳Beijing, Beijing, China
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
Mayo Clinic - Arizona
🇺🇸Phoenix, Arizona, United States
University of California Irvine
🇺🇸Orange, California, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
FirstHealth Cancer Center
🇺🇸Pinehurst, North Carolina, United States
University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Cemic
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de La Plata
🇦🇷La Plata, Buenos Aires, Argentina
Centro Medico Austral
🇦🇷Ciudad Autónoma de Buenos Aires, Distrito Federal, Argentina
Clinica Viedma
🇦🇷Viedma, Río Negro, Argentina
Exelsus Oncologia Clinica
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Fundacion Respirar
🇦🇷Buenos Aires, Argentina
Hospital Italiano
🇦🇷Capital Federal, Argentina
Sanatorio Allende
🇦🇷Córdoba, Argentina
Hospital Privado Universitario de Cordoba
🇦🇷Córdoba, Argentina
Centro Oncologico Riojano Integral
🇦🇷La Rioja, Argentina
GenesisCare -North Shore Oncology
🇦🇺St Leonards, New South Wales, Australia
Calvary Mater Newcastle Hospital
🇦🇺Waratah, New South Wales, Australia
The Queen Elizabeth Hospital
🇦🇺Woodville South, South Australia, Australia
Austin Health, Austin Hospital
🇦🇺Heidelberg, Victoria, Australia
Grand Hopital de Charleroi
🇧🇪Charleroi, Belgium