Shrunken Pore Syndrome's Effect on Mortality in Elective Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4,719
- 试验地点
- 1
- 主要终点
- Mortality during follow up
研究概览
简要总结
To study the impact a difference in renal clearance of small and large molecules has on long-term survival.
详细描述
Renal dysfunction is considered a major risk factor in cardiac surgery. Renal function has earlier been estimated by creatinine and more recently by cystatin C, both of which are analysed in a blood sample. New evidence seems to suggest that if the ratio between estimated renal function from cystatin C and creatinine is below 60% the patient has a higher rate of mortality irrespective of renal function. This syndrome is named Shrunken Pore Syndrome.
We study patients whom have undergone elective cardiac surgery at our institution and on whom we before the surgery has collected blood samples. They are all included in our in house patient registry and qulaity database and afterwards we match this data to our national tax registry to get data on mortality.
Our aim is to evaluate whether Shrunken Pore Syndrome influence mortality following elective cardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective CABG and/or sAVR at the department of Cardiothoracic Surgery, Skåne University Hospital in Lund, Sweden between 1 January 2010 and 31 December 2015.
排除标准
- •Emergency operation
- •Redo operation
- •Preoperatively missing cystatin C or creatinine
结局指标
主要结局
Mortality during follow up
时间窗: 1 January 2010 - 1 January 2019
All cause mortality at follow up
次要结局
未报告次要终点
研究者
Henrik Bjursten
Assoc. Prof
Region Skane
