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临床试验/NCT04141072
NCT04141072已完成不适用

Shrunken Pore Syndrome's Effect on Mortality in Elective Cardiac Surgery

Henrik Bjursten1 个研究点 分布在 1 个国家目标入组 4,719 人开始时间: 2010年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
4,719
试验地点
1
主要终点
Mortality during follow up

研究概览

简要总结

To study the impact a difference in renal clearance of small and large molecules has on long-term survival.

详细描述

Renal dysfunction is considered a major risk factor in cardiac surgery. Renal function has earlier been estimated by creatinine and more recently by cystatin C, both of which are analysed in a blood sample. New evidence seems to suggest that if the ratio between estimated renal function from cystatin C and creatinine is below 60% the patient has a higher rate of mortality irrespective of renal function. This syndrome is named Shrunken Pore Syndrome.

We study patients whom have undergone elective cardiac surgery at our institution and on whom we before the surgery has collected blood samples. They are all included in our in house patient registry and qulaity database and afterwards we match this data to our national tax registry to get data on mortality.

Our aim is to evaluate whether Shrunken Pore Syndrome influence mortality following elective cardiac surgery.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Elective CABG and/or sAVR at the department of Cardiothoracic Surgery, Skåne University Hospital in Lund, Sweden between 1 January 2010 and 31 December 2015.

排除标准

  • Emergency operation
  • Redo operation
  • Preoperatively missing cystatin C or creatinine

结局指标

主要结局

Mortality during follow up

时间窗: 1 January 2010 - 1 January 2019

All cause mortality at follow up

次要结局

未报告次要终点

研究者

发起方
Henrik Bjursten
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Henrik Bjursten

Assoc. Prof

Region Skane

研究点 (1)

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