Comparison of DXA to CT-based methods (CT Hounsfield unit attenuation value from the first lumbar vertebra [L1HU] and quantitative CT [QCT]) to detect osteoporosis and predict vertebral fracture in lung cancer screening participants

The University of Queensland0 sites94 target enrollmentOctober 11, 2021

Overview

No summary available.

Registry

who.int

Start Date

October 11, 2021

End Date

TBD

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Sponsor

•Participants enrolled in the ILST (men and women, aged 55\-80 years, current or former smokers quit \<15 years prior, \>\=30 pack\-year smoking history and/or estimated lung cancer risk \>\=1\.51% based on the PLCOm2012 risk prediction model, ECOG performance status 0 or 1\) who are also volunteers in the ILST osteoporosis sub\-study
•\-Participants who provide written consent.

•Exclusion criteria per ILST:
•Clinical symptoms suspicious for lung cancer
•Concurrent major medical illness (Any medical condition that, in the investigator’s opinion, may jeopardize the subject’s safety during participation in the study or mean that the subject is unlikely to benefit from screening due to shortened life expectancy)
•Previous lung cancer
•Other non\-curatively treated non\-pulmonary cancer or \<5 years cancer\-free if previous cancer
•Pneumonia/bronchitis requiring antibiotics within previous 12 weeks
•CT chest within the last 2 years
•Received chemotherapy/other cytotoxic drugs within the last 6 months
•Pregnancy
•Unwilling/unable to have chest CT