Phase II study of neoadjuvant chemotherapy with CPT-11 and S-1 for locally advanced colorectal cancer with lymph node metastases.
- Conditions
- locally advanced colorectal cancer with lymph node metastases
- Registration Number
- JPRN-UMIN000001698
- Lead Sponsor
- iigata Colorectal cancer Chemotherapy Study Group (NCCSG)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 35
Not provided
1)with serious interstitial lung fibrosis 2)with active double cancer 3)with active infection ,intestinal paralysis or ileus 4)with water solubility diarrhea 5)with uncontrolled diabetes mellitus 6)with serious complication (e.g. heart failure, hepatic failure, kidney failure) 7)receiving Flucytosine 8)pregnant or lactating women, women who are capable of pregnancy or intend to get pregnant 9with previous serious medical illness or allergy for drugs 10)with brain metastasis or treated for brain metastasis 11)with myelosupression 12)with pleural effusion or abdominal dropsy 13)with jaundice 14)receiving steroids 15)except referred to above, physician in charge of this trial gave a diagnosis the patient who can not joint this trail for the safety
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Response rate
- Secondary Outcome Measures
Name Time Method Relapse free survival of 3 years Overall survival Resection rate Safty Curative resection rate