JPRN-UMIN000004751已完成2 期
Evaluation of the Usefulness of Pre-operative Exemestane (EXE) Therapy for Treatment of Hormone-Sensitive Breast Cancer in Postmenopausal Patients, and EXE + Low-Dose CPA Combination Therapy for Nonresponders to EXE Therapy.(JBCRG-11CPA) - JBCRG-11CPA
Japan Breast Cancer Research Group (JBCRG)0 个研究点目标入组 59 人开始时间: 2010年12月20日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 59
研究概览
简要总结
Results Clinical response rates (CR and PR) at weeks 24 and 36 were 85% and 71%, respectively, in group A; and 54% and 71%, respectively, in group B. At week 36, no significant difference was found in median Ki67 index between the groups (3.5% and 4.0%). Conclusions Our findings provide support for the potential benefit of a tailored approach to neoadjuvant treatment in postmenopausal patients with ER-positive breast cancer.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- ot applicable 至 ot applicable（—）
- 性别
- Female
入选标准
- 未提供
排除标准
- •(1) Prior treatment for the breast cancer by chemotherapy or hormone therapy (2) Medication that may affect the sex hormone status (hormone replacement therapy, raloxifene, etc.) (eligible if the last dose was at least two months before) (3) Past history of breast cancer or presence of active multiple cancers (eligible if DCIS is located on the other side) (4) Bilateral breast cancer (if tumors on both sides meet the eligibility criteria, the case is not excluded.) (5) Cases for whom non-hormonal therapies such as surgical therapy, chemotherapy, or antibody therapy are recommended as the first treatment of choice (6) Past history of hypersensitivity to any drug or contrast agent used in this study (7) Cases in which another study drug is given for a disease other than breast cancer (8) Cases in which study participation is considered difficult due to the coexistence of psychosis or psychiatric symptoms (9) Cases considered ineligible by the attending physician for other reasons
研究者
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