The Effect of Alginate on Carbohydrate and Fat Digestion in a Mixed Meal

Not Applicable

Completed

• Conditions: Triacylglycerol Digestion
• Interventions: Dietary Supplement: Alginate Sausage; Other: Control Sausage

• Registration Number: NCT03860337
• Lead Sponsor: Newcastle University

Brief Summary

This study will investigate the effect of an extract of brown seaweed, called alginate, on fat digestion. The extract has been cooked into sausages and the alginate sausages will be compared to the same sausages that do not contain alginate. People taking part in the study will come to the study centre twice. Once to have the alginate sausage meal or the normal sausage meal and on the second visit they will have the other meal so then end up having had both types of sausages. The level of fat in their blood will be monitored over the four hours after the meal. The rate and amount of fat that moves into the blood after a meal is an indication of the amount of fat digestion. We believe that less fat will be digested and move into the blood when the volunteers eat the alginate sausages compared to the normal sausages.

Detailed Description

Alginate is an extract of brown seaweed and has been shown to reduce lipase activity in vitro. Lipase is a valid target for anti-obesity products as shown by the pharmaceutical drug orlistat which targets the same enzyme. Reducing the amount of lipase activity will reduce the amount of triacylglycerol (TAG) that will be digested and therefore absorbed and will be seen as a reduction in the level of circulating TAG in the blood. Adding alginate to a range of food products that are simple to include into the diet could help with the management of obesity. In this study, sausages containing alginate have been manufactured for us along with matched control sausage. The circulating TAG in the blood will be measured via fingerpick blood samples every 30 minutes for four hours after the volunteers have eaten either alginate sausages or normal sausages. The volunteers will come for two visits and consume the other sausage meal at the second so they will have had both types of sausage.

Study Timeline

• Study First Submitted: 2019-02-28
• Study First Submitted QC: 2019-02-28
• Study First Posted: 2019-03-01
• Study Start: 2019-05-13
• Primary Completion: 2019-06-19
• Study Completion: 2019-06-19
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-27
• Last Update Posted: 2019-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Exclusion Criteria

• pregnant or lactating.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control then Alginate	Control Sausage	This group will be given the control then alginate sausages
Alginate then Control	Alginate Sausage	This group will be given the alginate then the control sausages
Alginate then Control	Control Sausage	This group will be given the alginate then the control sausages
Control then Alginate	Alginate Sausage	This group will be given the control then alginate sausages

Primary Outcome Measures

Name	Time	Method
Concentration of circulating TAG in blood	4 hours after the test meal	mmol/L

Secondary Outcome Measures

Name	Time	Method
Concentration of circulating glucose in blood	4 hours after the test meal	mmol/L

Trial Locations

Locations (1)

Newcastle University; 🇬🇧 Newcastle, Tyne And Wear, United Kingdom