Effects of Transcranial Direct Current Stimulation on Fine Motor Skills in Parkinson's Disease: a Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- KU Leuven
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Change in writing amplitude
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this pilot study is to determine the effect of transcranial direct current stimulation (tDCS) on brain activity and fine motor skills in patients with Parkinson's disease compared to healthy controls.
Detailed Description
The pilot study will involve a double-blind, sham controlled cross-over design where participants will receive anodal and sham tDCS stimulation in a randomized order. Differences in brain activity and fine motor skill performance between groups and after tDCS stimulation will be compared.
Investigators
Alice Nieuwboer
Professor
KU Leuven
Eligibility Criteria
Inclusion Criteria
- •Diagnosed with idiopathic PD, according to the UK Brain Bank criteria
- •Hoehn and Yahr (H\&Y) stage II in the 'on'-phase of the medication cycle
- •Right dominant PD
Exclusion Criteria
- •Cognitive impairment (MMSE \< 23)
- •Visuo-spatial deficits (measured by the Rey-Osterrieth Complex Figure (ROCF) test)
- •Left-handedness (evaluated by the Edinburgh Handedness scale)
- •Depression
- •Pregnancy
- •Alcohol abuse
- •Aneurysm clips
- •Pacemaker
- •Neurostimulator
- •Implemented defibrillator
Outcomes
Primary Outcomes
Change in writing amplitude
Time Frame: post-stimulation (immediately after) and retention (1 week)
Centimeter (cm)
Change in writing velocity
Time Frame: post-stimulation (immediately after) and retention (1 week)
Centimeter per second (cm/s)
Secondary Outcomes
- Change in cortical silent period (cSP)(post-stimulation (immediately after) and retention (1 week))
- Change in speed on the Purdue Pegboard task(post-stimulation (immediately after) and retention (1 week))
- Change in cortical excitability(post-stimulation (immediately after) and retention (1 week))
- Change in Short-Latency Intracortical Inhibition (SICI)(post-stimulation (immediately after) and retention (1 week))