Radiotherapy for Malignant Astrocytomas in the Elderly

Phase 3

Completed

• Conditions: Primary Brain Tumor; Anaplastic Astrocytoma; Glioblastoma Multiforme

• Registration Number: NCT00430911
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

A randomized trial comparing radiotherapy with supportive care in patients aged 70 years or older with newly diagnosed, histologically confirmed anaplastic astrocytoma or glioblastoma, and a Karnofsky performance status \> 70.

Detailed Description

Not available

Study Timeline

• Study Start: 2001-02
• Status Verified: 2007-01
• Study First Submitted: 2007-01-31
• Study First Submitted QC: 2007-01-31
• Last Update Submitted: 2007-01-31
• Study First Posted: 2007-02-02
• Last Update Posted: 2007-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Glioblastoma and anaplastic astrocytoma, supratentorial, histologically confirmed
• Brain CT scan or MRI within 28 days before surgery
• Age: 70 years or older
• Karnofsky performance status, 70 or more.
• Life expectancy over 12 weeks
• Informed consent

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Exclusion Criteria

• Brain radiotherapy
• Chemotherapy
• Severe systemic disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Survival

Secondary Outcome Measures

Name	Time	Method
Progression free survival
Quality of life
Cognitive functions

Trial Locations

Locations (1)

Hôpital de la Salpêtrière; 🇫🇷 Paris, Ile de France, France