Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario

Completed

• Conditions: Irritable Bowel Syndrome

• Registration Number: NCT00235326
• Lead Sponsor: McMaster University

Brief Summary

Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases (IBD).

Detailed Description

This research will study chronic gastrointestinal problems in the residents of Walkerton, Ontario region. Determine whether acute bacterial infection is a risk factor for development of inflammatory bowel disease using the population of Walkerton as a cohort. We hypothesize that exposure to bacterial infection leads to development of post infectious irritable bowel syndrome which is associated with an increase in intestinal permeability and immune activation with low grade intestinal inflammation and that this sequence of events will trigger inflammatory bowel disease in genetically susceptible individuals

Study Timeline

• Study Start: 2002-01
• Study First Submitted: 2005-10-06
• Study First Submitted QC: 2005-10-06
• Study First Posted: 2005-10-10
• Primary Completion: 2008-08
• Study Completion: 2008-08
• Results First Submitted: 2009-02-05
• Status Verified: 2009-03
• Results First Submitted QC: 2009-03-16
• Last Update Submitted: 2009-03-16
• Results First Posted: 2009-04-22
• Last Update Posted: 2009-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4561

Inclusion Criteria

• Participants must be residents of the Walkerton, Ontario region at the time of Outbreak who consented to the study

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Exclusion Criteria

• Non residents of Walkerton Ontario at the time of outbreak

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of Participants With Post Infectious Irritable Bowel Syndrome	8 years

Trial Locations

Locations (1)

Walkerton; 🇨🇦 Walkerton, Ontario, Canada