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临床试验/NCT00654134
NCT00654134已完成1 期

Inhalation of 20,000 EU of Clinical Center Reference Endotoxin in Healthy Volunteers

University of North Carolina, Chapel Hill2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2005年10月最近更新:
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适应症

试验速览

阶段
1 期
状态
已完成
入组人数
20
试验地点
2
主要终点
To determine the inflammatory response to 20,000 endotoxin units (EU) of CCRE (Clinical Center Reference Endotoxin) inhalation in a cohort of healthy volunteers.
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to determine the inflammatory response to 20,000 endotoxin units (EU) of CCRE (Clinical Center Reference Endotoxin) inhalation in a cohort of healthy volunteers. Preferably these subjects will have participated in ozone exposure studies, allowing a direct comparison of their responses to both endotoxin and ozone. Additionally, cardiovascular endpoints will be investigated with the CCRE exposure.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 50 Years（Adult）
性别
All
接受健康志愿者
是

入选标准

  • •Prior participation in Ozone Study
  • •Healthy adults
  • •Nonsmokers
  • •No chronic illness
  • •No active allergies

排除标准

  • •Reduced Lung function

结局指标

主要结局

To determine the inflammatory response to 20,000 endotoxin units (EU) of CCRE (Clinical Center Reference Endotoxin) inhalation in a cohort of healthy volunteers.

时间窗: 6 hours post challenge

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Michelle Hernandez, MD

Assistant Professor of Pediatrics

University of North Carolina, Chapel Hill

研究点 (2)

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