Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance-volume Profile in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Intratidal compliance profiles in each ventilator settings
研究概览
简要总结
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
Then determine the most appropriate combination of positive end-tidal pressure and tidal volume.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children undergoing surgery > 1 hour under general anesthesia
- •Children ≤ 6 years
- •American society of anesthesiology physical status I, II
排除标准
- •Previous lung surgery
- •Bronchopulmonary dysplasia, respiratory distress syndrome
- •Other interstitial lung disease
- •Laparoscopic surgery
- •Thoracic surgery, abdominal surgery
研究组 & 干预措施
Evaluation of intratidal compliance
When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order.
- Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg
- Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg
- Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg
- Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg
干预措施: Changes in positive end-expiratory pressure and tidal volume (Other)
结局指标
主要结局
Intratidal compliance profiles in each ventilator settings
时间窗: During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
The investigators will determine Intratidal compliance profile using the changes in compliance over time --\> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high.
次要结局
- Driving pressure(During general anesthesia (up to about 50 min-1 hr after induction of anesthesia))
- Respiratory compliance(During general anesthesia (up to about 50 min-1 hr after induction of anesthesia))
- Blood pressure(During general anesthesia (up to about 50 min-1 hr after induction of anesthesia))
研究者
Jin-Tae Kim
Professor
Seoul National University Hospital