Physical Activity, Nutrition and Health: Influence of a training and nutritional intervention on health-related parameters of yet physically inactive people
- Conditions
- Physical inactivity
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 134
consent men and women
- 50 - 70 years
- so far physically inactive people who have not carried out specific sports activities outside of their daily activities for at least 2 years
- sports capability
- willingness to independently perform a training program for 12 weeks
- willingness to implement given dietary recommendations in everyday life
- willingness to take a multivitamin mineral preperation daily for 12 weeks
- willingness to be assigned to the waiting control group and to receive the intervention after a waiting period of 12 weeks
- stable weight since min. half a year (± 5 kg)
- omnivorous diet
- severe chronic diseases (cancer, type 1 diabetes, etc.), manifest cardiovascular diseases, renal insufficiency, liver disease
- chronic diseases of the gastrointestinal tract (e.g., ulcerative colitis, Crohn's disease, pancreatic insufficiency)
- blood coagulation disorders
- known immunological disorders (e.g., autoimmune diseases)
- regular intake of laxatives
- permanent use of immunosuppressive drugs (cortisone, anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, etc.)
- drug, alcohol and medication abuse
- non-consenting subjects
- simultaneous participation in another clinical study or participation within the past 30 days
- ingestion of mineral and / or vitamin supplements, unless discontinued 6-8 weeks prior to study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determination of the CD4 / CD8 ratio of T-cells in venous blood at the beginning and at the end of the twelve-week intervention.
- Secondary Outcome Measures
Name Time Method At the beginning and end of the intervention, the following parameters will be determined from venous blood:<br>- i.a. immunological parameters, e.g. number of regulatory T-cells, T-cell apoptosis and activation markers (Annexin V and CD69)<br>- i.a. biochemical parameters (e.g., parameters of iron metabolism, vitamin B12 (cobalamin)),<br>- i.a. Health status survey (e.g., SF36)<br>- i.a. Survey of diet and exercise behavior (e.g., FFQ, Freiburger Fragebogen questionnaire on physical activity)<br>- anthropometric data