Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13

Phase 2

Completed

• Conditions: Opioid-Related Disorders; Alcohol-Related Disorders; Substance-Related Disorders
• Interventions: Drug: 30% Nitrous oxide; Other: Placebo; Drug: 0.2% sevoflurane; Drug: 0.4% sevoflurane; Drug: 0.6% sevoflurane

• Registration Number: NCT00000261
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers. All subjects underwent psychomotor testing during 4 sessions of placebo, drug/placebo, and choice of intervention.

Detailed Description

Not available

Study Timeline

• Study Start: 1997-11
• Primary Completion: 1998-10
• Study Completion: 1998-10
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Moderate drinking adults	0.2% sevoflurane	-
Moderate drinking adults	0.6% sevoflurane	-
Moderate drinking adults	30% Nitrous oxide	-
Moderate drinking adults	Placebo	-
Moderate drinking adults	0.4% sevoflurane	-

Primary Outcome Measures

Name	Time	Method
Psychomotor performance	Baseline, inhalation, recovery
Mood	Baseline, inhalation, recovery
Choice of drug vs placebo	After placebo and drug in each session

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States