The Impact of Age, Genes, Training and History of Tickbourne Disease on Endurance Performance in Elite Endurance Athletes.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Time trail cross-country roller skiing performance
研究概览
简要总结
Several studies have investigated determinant factors for endurance performance among different athletes, untrained individuals and patients focusing on the impact of age, genes and training intensity. A further step in this research will be to investigate the impact of age, genes, training intensity and history of tick-bourne disease on endurance performance in elite endurance athletes. We are planning a project with a two-step model. In step one we will, in a cross-sectional study design, investigate potential relationships between age, training intensity, training volume, genes, exosomes and history of tick-bourne disease and physiological variables and endurance performance. In step two we will investigate differences in training adaptation by observing and monitoring all training done by the participants during a 6-months period. The participants will be tested for several physiological variables before, after 3- months and after this period. We will also investigate the impact of age, training intensity, training volume, genes and history of tick-bourne disease on the results from the physiological tests and performance.
详细描述
The study will be designed in a two-step model. In the first step, we will investigate potential relationships between age, genes, exosomes, miRNA, training intensity, and history of tick-borne disease, and physiological laboratory-tests and performance in a roller-skiing performance test. This study will have a cross-sectional design. In the second step we will examine potential differences in training adaptations to a 6-months observation of self-selected training. We then will categorize the athletes into three groups, based on training volume and training intensity. We will then investigate possible relationships between training volume and training intensity and physiological variables, genes, age and possible history of tick-bourne disease.
STEP 1: Cross-sectional study:
Since the aim of the study is to investigate effects of age, genes, exosomes, training and history of tick-borne disease on training adaptations and endurance performance in elite endurance athletes, we will recruit active cross-country skiers from 16 - 50 years. These athletes have shown to have some of the highest aerobic capacities in the world (Ingjer, 1991).
Both males and females will be included for participation in this project, and we will try to include equal amount of both sexes. The athletes will be recruited from relevant, cross-country skiing milieus in Southeast Norway by open invitation and advertisement. Invited athletes must sign a declaration for participation and a declaration of health status, before participation. In the declaration for participation, the athletes will be informed briefly about the background of this project, which tests they are going to take, and how these tests will be performed and how the results are being contained and presented.
Statistical analysis will be as descriptive statistics, and simple and multiple regressions- and correlation analysis in the cross-sectional study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 16 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 16 and 50
- •active competition athletes competing on a national level or above
- •athletes who write training diaries
排除标准
- •Sickness and/or injury who contra indicates normal training and maximal testing.
- •An on-going infection or injury.
结局指标
主要结局
Time trail cross-country roller skiing performance
时间窗: Change from baseline performance at 3-months and at 6-months
Testing of seconds used in a predefined track
Maximal oxygen consumption
时间窗: Change from baseline maximal oxygen uptake at 3-months and at 6-months
Standard ergospirometrical incremental test in running and double-poling
次要结局
- Lactate threshold in double poling(Change from baseline lactate threshold at 3-months and at 6-months)
- Double poling economy(Change from baseline economy at 3-months and at 6-months)
- Age(Baseline)
- Maximal power(Change from baseline power at 3-months and at 6-months)
- Maximal strength(Change from baseline maximal strength at 3-months and at 6-months)
- Jump height(Change from baseline jump height at 3-months and at 6-months)
- Tick-bourne disease(Baseline)
- Genotypes(Baseline)
- Exosomes(Baseline)
- Training intensity(Change from baseline training intensity at 3-months and at 6-months)
- Training volume(Change from baseline training volume at 3-months and at 6-months)