Time-Restricted Eating as an Adjunctive Intervention for Bipolar Disorder: Acceptability and Feasibility
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bipolar Disorder
- Sponsor
- University of California, Berkeley
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- Acceptability as assessed using self-ratings on items designed for this study
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
This is a pilot trial to examine the acceptability and feasibility of time-restricted eating as an adjunct to medication treatment for bipolar disorder.
Detailed Description
Time-restricted eating (TRE) is a way of scheduling food intake that has been shown to improve circadian rhythms in animals and humans. TRE is based on animal and human science that shows that the timing of eating powerfully influences diurnal rhythms. Animal research has shown that feeding during sleep periods leads to a surge of norepinephrine, cortisol, wakefulness, and activity. Drawing on this, over a decade of studies have examined the impact of experimentally randomizing mice to time-restricted feeding during wake hours (vs. 24-hour ad libitum feeding). Importantly, caloric intake and other facets of diet were yoked for strict control. A consistent finding is that TRE had powerful benefits for circadian and metabolic indicators across studies,and more recent data also shows benefit for animal longevity. Here, the investigators' goal is to extend this work to bipolar disorder (BD). More specifically, the investigators will gather data to examine the acceptability and feasibility of TRE among those who self-identify with bipolar disorder and who experience some problems with sleep, circadian rhythms, or schedules. The investigators will gather measures of mania, depression, sleep, and QOL, to provide preliminary evidence of change on these dimensions.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adults diagnosed with bipolar disorder and currently receiving medical care for their bipolar disorder.
- •Experiencing schedule/sleep or circadian problem in the past 3 months
- •Medication regimens stable for past month
- •Adequate English language skills for taking part in the program.
- •Living in California.
Exclusion Criteria
- •Cognitive deficits (Screening OMC Test)
- •Current: psychosis, (hypo)mania, major depressive episode, substance/alcohol use disorders, eating disorder diagnoses or acute suicidal risk (MINI interview; see DSM5 TRE screening)
- •High scores (\> 5) on the Screening Eating Disorder Examination Questionnaire
- •Current shift work
- •\>5 kg weight change within 3 months
- •Pregnancy
- •Breastfeeding
- •Uncorrected hypo or hyperthyroidism
- •\* diabetes type 1
- •Gastrointestinal conditions impairing nutrient absorption
Outcomes
Primary Outcomes
Acceptability as assessed using self-ratings on items designed for this study
Time Frame: Immediately post-treatment (10 weeks)
self-ratings of the acceptability of the intervention
Feasibility as assessed by percent of clients who complete the assessments and intervention
Time Frame: Immediately post-treatment (10 weeks)
Percentage of clients who do not drop out of the trial. Drop out would be defined as not completing the TRE intervention, or failing to complete the end-of-treatment intervention.
Secondary Outcomes
- Lower scores on two Patient Reported Outcome Measurement Information System (PROMIS) sleep scales(Change from baseline to immediately post-treatment (10 weeks))
- higher scores on Self-rated Quality of Life(Change from baseline to immediatly post-treatment (10 weeks))
- Lower Mania symptoms as assessed with the Patient Mania Questionnaire-9(Change from baseline to immediately post-treatment (10 weeks))
- Lower Depression symptoms as assessed with the Patient Health Questionnaire-9(Change from baseline to immediately post-treatment (10 weeks))