Safety and performance of trehalose hyaluronic acid versus standard infiltrative therapy based on medium weight sodium hyaluronate in knee joint osteoarthritis treatment

Phase 4

Completed

• Conditions: Osteoarthritis of the knee; Musculoskeletal Diseases; Gonarthrosis [arthrosis of knee]

• Registration Number: ISRCTN18428696
• Lead Sponsor: OASI Bioresearch Foundation

Brief Summary

2022 Results article in https://doi.org/10.1016/j.jcjp.2022.100043 (added 09/11/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-30
• Study Completion: 2021-10-01
• Last Update Posted: 20 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aged 18 to 80 years
2. Symptomatic knee osteoarthritis, grade I to III according to Kellgren and Lawrence classification
3. Without pain relief after at least 3 months of non-invasive treatment
4. Osteoarthritis diagnosed by x-ray and classified according to Kellgren and Lawrence classification

Exclusion Criteria

1. Any recent intra-articular injection therapy
2. Knee instability
3. Significant axial deviation
4. Systemic disorders such as rheumatoid arthritis, coagulopathies, or infections

Study & Design

• Study Type: Interventional
• Study Design: Not specified