Effects of proton pump inhibitor treatment on apnea severity in patients with laryngopharyngeal reflux and obstructive sleep apnea

McGill University Health Centre Research Institute (Canada)0 个研究点目标入组 44 人开始时间: 2007年1月5日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Adults 20 to 70 years with untreated obstructive sleep apnea, non-smoking
•2. Epworth sleepiness score less than 15
•3. Apnea-hypopnea index of 15 to 60 events per hour, with Non-Rapid Eye Movement Apnea Hypopnea Index (NREM AHI) more than 10, nadir Saturation of Oxygen in arterial blood (SaO2) more than or equal to 80% at overnight polysomnography
•4. Reflux Finding Score more than 7 on laryngoscopy

•1. Any prior treatment for OSA
•2. Current or past proton pump inhibitor therapy, current inhaled or systemic corticosteroid, or systemic immunosuppressive treatment
•3. Active cardiovascular disease (uncontrolled hypertension, unstable angina, myocardial infarction within the preceding six months, congestive heart failure)
•4. Epworth Sleepiness Score more than 15 or employment in a safety critical position regardless of Epworth Score
•5. History of a bleeding disorder
•6. Otolaryngologic conditions including glottic or subglottic stenosis, cancer of the larynx, previous radiotherapy, upper airway surgery other than remote tonsillectomy, or major craniofacial malformation

发起方

McGill University Health Centre Research Institute (Canada)