The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Oklahoma
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty
Study Overview
Brief Summary
This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.
Detailed Description
Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention
Exclusion Criteria
- •Acute coronary syndrome
- •Unable to tolerate clopidogrel
Outcomes
Primary Outcomes
The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty
Time Frame: 24 hours after the administration of clopidotrel
The percentage of platelets that are collagen coated after the administration of clopidogrel.
Secondary Outcomes
- The Percentage of Coated Platelets After Coronary Angiography and/or PCI(6 hrs after procedure)