The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

Not Applicable

Completed

• Conditions: Coronary Artery Disease; Chest Pain

• Registration Number: NCT00644657
• Lead Sponsor: University of Oklahoma

Brief Summary

This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.

Detailed Description

Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2008-03-24
• Study First Submitted QC: 2008-03-26
• Study First Posted: 2008-03-27
• Primary Completion: 2008-09
• Study Completion: 2008-09
• Results First Submitted: 2011-01-06
• Status Verified: 2011-09
• Results First Submitted QC: 2011-09-07
• Last Update Submitted: 2011-09-07
• Results First Posted: 2011-10-07
• Last Update Posted: 2011-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention

Exclusion Criteria

• Acute coronary syndrome
• Unable to tolerate clopidogrel

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty	24 hours after the administration of clopidotrel	The percentage of platelets that are collagen coated after the administration of clopidogrel.

Secondary Outcome Measures

Name	Time	Method
The Percentage of Coated Platelets After Coronary Angiography and/or PCI	6 hrs after procedure	The percentage of coated platelets 24 hours after coronary angiography and/or PCI

Trial Locations

Locations (1)

VA Medical Center, 1F187; 🇺🇸 Oklahoma City, Oklahoma, United States