Investigation of Red and White Blood Cell Deformability in Sepsis Patients using RT-DC Technique

• Conditions: A40; A41; R65; Streptococcal sepsis; Other sepsis; Systemic Inflammatory Response Syndrome [SIRS]

• Registration Number: DRKS00023225
• Lead Sponsor: Institute of Bioinformatics, University Medicine Greifswald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Intensive care patient with suspected sepsis

Exclusion Criteria

none

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analysis of the RT-DC parameters / cell deformation, especially of the leukocytes in the clinical course (analysis of the kinetics), which are characterized by changes in cell size, deformation and brightness, in relation to the actual sepsis onset.

Secondary Outcome Measures

Name	Time	Method
RT-DC measurements at different times to analyze the same blood sample 1h, 2h, 4h, 8h after blood sampling to clarify the questions:<br>How quickly does the fresh blood have to be analyzed? How stable are the measurements?<br><br>Comparison of the RT-DC parameters with proven infection parameters CRP, PCT, IL-6 (correlation analysis, analysis of the significance of the new parameters)<br>