Feasibility and Effectiveness of a 12-week Concurrent Exercise Training on Physical Performance, Muscular Strength and Circulating Myokines in Frail Older Adults Living in Nursing Homes: a Cluster Randomized Crossover Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- Universidade do Porto
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- Change from Baseline on Short Physical Performance Battery (SPBB)
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The present study is a crossover randomized controlled trial that aims to investigate the effects of concurrent exercise training over usual care on physical performance, muscle strength, and myokines concentrations in frail older adults living in nursing homes.The main questions it aims to answer is: Can a 12-week exercise intervention provide beneficial effects on physical performance, muscle strength and myokines among the most frail participants? Researchers will compare this intervention to usual care. Nursing homes (comprising participants) will be randomly assigned to a sequence of interventions (AB or BA), being A -exercise and B usual care. Participants will be assessed before and after each intervention.
Detailed Description
The present study is a crossover randomized controlled trial that aims to investigate the effectiveness of a concurrent exercise training over usual care on physical performance, muscle strength, and myokines concentrations in frail older adults living in nursing homes. Nursing homes will be randomly assigned to receive a sequence of interventions (AB or BA), being A -exercise and B usual care. Participants will receive a 12-weeks of either exercise intervention or usual care. A 4-week washout period will be conducted between interventions. Participants will assessed before and after each intervention.
Investigators
Maria Joana Carvalho
Principal Investigator
Universidade do Porto
Eligibility Criteria
Inclusion Criteria
- •Classified as frail according to the Fried criteria (e.g., frailty phenotype ≥ 3 criteria);
- •Not having participated in any exercise intervention for the last 3 months;
- •Being able to ambulate (with/without assistance).
Exclusion Criteria
- •Any contraindication that could affect physical exercise performance or testing procedures, including terminal illness, uncontrolled disease or other unstable medical condition;
- •Bone fracture in the past three months;
- •having a short physical performance battery score (SPPB) \< 3.
Outcomes
Primary Outcomes
Change from Baseline on Short Physical Performance Battery (SPBB)
Time Frame: Assessment at baseline and immediately after 12 weeks of intervention, in each period.
The Short Physical Performance Battery (SPPB) is a standardised assessment tool of lower limb function, testing 3 dimensions: standing balance, walking speed, and chair stands. Each component is scored between 0-4, total score from 0 (poor performance) to 12 (best performance).
Secondary Outcomes
- Change from Baseline on circulating levels of myostatin(Change from baseline and 12 weeks in each intervention, in both periods)
- Change from baseline on isokinetic knee strength(Change from baseline and 12 weeks in each intervention, in both periods)
- Change from Baseline on Handgrip test(Assessment at baseline and immediately after 12 weeks of intervention, in each period)
- Change from Baseline on circulating levels of Decorin(Assessment at baseline and immediately after 12 weeks of intervention, in each period)