Effect of rTMS with and without CCR in treatment of the bipolar disorder

Not Applicable

• Conditions: Bipolar Disorder.; Bipolar disorder

• Registration Number: IRCT20220321054335N1
• Lead Sponsor: Atieh Clinical Neuroscience Center (ACNC)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 November 2022

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

All adults diagnosed with bipolar disorder by psychologists and psychiatrists
Minimum education in reading and writing

Exclusion Criteria

History of epilepsy or convulsions in the person or first degree relatives
Having acute heart disease
No history of drug use and head trauma
Pregnant or breastfeeding women
The presence of intracranial implants (such as shunts, electrodes) or any other metal object in or near the head (such as the mouth)
Having a pacemaker

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The score of Bipolar Depression Rating Scale (BDRS). Timepoint: Evaluation of mood symptoms before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: Bipolar Depression Rating Scale (BDRS).;Evaluation of cognitive functions by Cantab. Timepoint: Evaluation of cognitive functions before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: the Cambridge Neuropsychological Test Automated Battery (CANTAB) will be used.;Power of frequency bands in rest condition and changes of P300 component during Go-NoGo task (using Mitsar EEG recording device). Timepoint: Evaluation of brain signal before the start of the intervention and after the last session of TMS and CCR treatment. Method of measurement: by 19-channel EEG device during rest and Go-NoGo task.