Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Frequency of sinusitis
研究概览
简要总结
The propose of this study to determine efficacy and complication of gentamicin nasal irrigation in chronic rhinosinusitis
详细描述
Chronic rhinosinusitis (CRS) is characterized by symptoms > 12 weeks
Two or more symptoms one of which should be either nasal blockage /obstruction/congestion or nasal discharge (anterior/posterior nasal drip):
- facial pain/pressure
- reduction or loss of smell)
Mainstay of treatment are medical and surgical treatment ( ATB, adenoidectomy, ESS) Adjunctive treatment : normal saline nasal irrigation, nasal corticosteroids, nasal decongestants, mucolytics Topical antibiotic therapy in patients with refractory sinusitis has been shown to improve symptoms, quality of life, and mucosal aspect Nasal lavage with Mupirocin represent an effective and well tolerated alternative treatment of surgically recalcitrant chronic rhinosinusitis
In pediatrics allergy clinic at Siriraj hospital since 2006 use Gentamicin nasal irrigation for chronic rhinosinusitis.There have been no studies in gentamicin irrigation in chronic rhinosinusitis. The aims of this study are to evaluate:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic rhinosinusitis patients who were followed in pediatrics allergy clinic at Siriraj hospital between January 1, 2005, and February 28, 2011
- •Gentamicin nasal irrigation usage for longer than 3 months
排除标准
- •Patients who used azithromycin prophylaxis within 1 year before and 6 months after started gentamicin nasal irrigation
- •Patients received IVIG within 1 year before and 6 months after started gentamicin nasal irrigation
- •Patients underwent endoscopic sinus surgery within 1 year before and 6 months after started gentamicin nasal irrigation
- •Patients received IT within 1 year before and 6 months after started gentamicin nasal irrigation
结局指标
主要结局
Frequency of sinusitis
时间窗: 1 year
次要结局
- Complications of gentamicin nasal irrigation usage(1 year)
- Frequency of antibiotic usage(1 year)
研究者
Nualanong Visitsunthorn
Professor
Mahidol University