Effect of Oliceridine on Rebound Pain

Recruiting

• Conditions: Rebound Pain; Arthroscopic Knee Surgery; Oliceridine
• Interventions: Other: No intervention

• Registration Number: NCT06382896
• Lead Sponsor: The First Affiliated Hospital of Xiamen University

Brief Summary

The purpose of this clinical study was to identify the risk factors for postoperative pain outburst in patients undergoing arthroscopic knee surgery after Oliceridine and nerve block, and to evaluate the effect of oxeridine on early rehabilitation exercise in patients. A total of 320 patients undergoing arthroscopic knee arthroscopy under general anesthesia combined with femoral nerve block were selected to record the time and duration of postoperative pain outbreak, pain degree, age, gender, operation type, previous surgical history and other related risk factors.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2024-04
• Study First Submitted: 2024-04-15
• Study First Submitted QC: 2024-04-18
• Last Update Submitted: 2024-04-23
• Study First Posted: 2024-04-24
• Last Update Posted: 2024-04-25
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 320

Inclusion Criteria

1. Age 18-70 years old;2. Body mass index (BMI) 18-30kg /m2;3. American Society of Anesthesiologists (ASA) Grade I to II;4. Hospital stay >24h.

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Exclusion Criteria

1. Patients who cannot understand the numerical rating scale score and give feedback;2. Known allergy to the drug in the study;3. Infection of puncture site with nerve block;4. Oral analgesics for more than 2 weeks before surgery;5. Long-term use of glucocorticoids;6. Simultaneous surgery on both limbs;7. A psychopath;8. Severe compound trauma;9. Pregnant and lactating women.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients undergoing ambulatory arthroscopic knee surgery	No intervention	-

Primary Outcome Measures

Name	Time	Method
The degree of the rebound pain	Within 48 hours after surgery	The numerical rating scale was used
Previous surgical history	Within 48 hours after surgery	Fill in the postoperative questionnaire
Time of onset of postoperative rebound pain	Within 48 hours after surgery	The numerical rating scale was used
The duration of the rebound pain	Within 48 hours after surgery	The numerical rating scale was used
age	Within 48 hours after surgery	Fill in the postoperative questionnaire
sex	Within 48 hours after surgery	Fill in the postoperative questionnaire
Surgical procedure	Within 48 hours after surgery	Fill in the postoperative questionnaire

Secondary Outcome Measures

Name	Time	Method
Movement recovery time	Within 7 days of surgery	Fill in the postoperative questionnaire

Trial Locations

Locations (1)

First Affiliated Hospital of Xiamen University; 🇨🇳 Xiamen, Fujian, China