Comparison of skin disinfection procedures before surgery to determine if surgical wound contamination by skin bacteria can be reduced.
Not Applicable
Completed
- Conditions
- Spinal surgical site wound contamination by bacteria and the implications for post-surgical infectionSurgerySpinal surgery
- Registration Number
- ISRCTN73863246
- Lead Sponsor
- Queen’s University Belfast
- Brief Summary
2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28963158
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
1. Undergoing spinal surgery
2. Aged 18 and over
Exclusion Criteria
1. More than 7 days of hospitalisation before surgery
2. Transferred from another hospital
3. Overt spinal infections suspected preoperatively or evidence of purulence in any part of the wound during surgery
4. Sensitivity to the skin antiseptics
5. On antibiotics before surgery, other than surgical prophylaxis, because antibiotics can be excreted in sweat and could therefore affect the normal resident skin bacteria
6. Patients aged less than 18 years old
7. Pregnant women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Aerobic and anaerobic bacterial growth in each of the tissue samples.<br> Outcomes relate to the bacteria cultured from the samples obtained at the time of surgery and the subsequent analyses of these bacteria. No outcomes relating to patients.<br>
- Secondary Outcome Measures
Name Time Method <br> 1. To determine if the bacteria cultured from the surgical wounds are the same or different from bacteria on the patient's skin<br> 2. Pure cultures of bacteria will be archived and identified subsequently using polymerase chain reaction DNA amplification and DNA sequence analyses<br> 3. Antimicrobial resistance genes will also be examined<br>