Electrical Stimulation for Restoration of Vision After Stroke in the Damaged Visual Field of Patients With Unilateral Stroke (REVIS Helsinki)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Helsinki University Central Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Improved detection in the visual field defined as the percentage change of the stimulus detection rate in High-resolution perimetry (HRP)
- Last Updated
- 11 years ago
Overview
Brief Summary
Occipital stroke is associated with homonymous visual field defects (occurring on one side of the visual field). Despite spontaneous recovery, some degree of defect is often permanent. Currently, no treatment exists for such visual field defects.The purpose of this study is to test the efficacy of a type of electrical brain stimulation method, transcranial alternating current stimulation, in reducing these type of visual field defects in their chronic stage.
Investigators
Turgut Tatlisumak, MD, PhD, FAHA, FESO
Associate Professor
Helsinki University Central Hospital
Eligibility Criteria
Inclusion Criteria
- •Occipital ischemic or hemorrhagic stroke 6 months or older
- •Hemianopia or quadrantanopia demonstrated by standard automated perimetry
- •Visual field defect is stable across baseline
- •Presence of residual vision and detectable gradual transition between the the intact and absolutely blind parts of the visual field
- •Best corrected visual acuity for at least one eye better or equal to 0.4
Exclusion Criteria
- •Eye or central nervous system disease that interferes with the study
- •Cardiac pacemaker
- •Other metallic devices or implants precluding participation in MRI scans
- •Pregnancy or lactation period
- •Epileptic seizures in the past 10 years
- •Use of antiepileptic or sedative drugs
- •Expected low compliance due to substance abuse
- •Known active malignancy
Outcomes
Primary Outcomes
Improved detection in the visual field defined as the percentage change of the stimulus detection rate in High-resolution perimetry (HRP)
Time Frame: Change between 3-7 days pre-treatment, at 3-7 days post-treatment, and at 2 months post-treatment
HRP is a computer-based perimetry using a supra-threshold stimulus. It is used to detect residual vision between the absolute defect and seeing field and to monitor subtle changes in perceptual ability. HRP is performed in fixation control using an eye tracker. The primary outcome measure will be the percentage change in HRP detection accuracy between pre-test and post-test measurements.
Secondary Outcomes
- The change in extent of visual fields in standard automated perimetry(Change between 3-7 days pre-treatment, at 3-7 days post-treatment, and at 2 months post-treatment)