Effect Of Delta Sodium on the Postoperative Outcomes in Liver Transplant Recipients

Completed

• Conditions: Liver Transplant; Complications; Electrolyte Disturbance; Perioperative/Postoperative Complications
• Interventions: Other: Collecting sodium reports and outcome measures

• Registration Number: NCT04112004
• Lead Sponsor: Institute of Liver and Biliary Sciences, India

Brief Summary

We analyzed the association of delta sodium levels with their effect on post liver transplant outcomes in consecutive patients undergoing liver transplantation. Records were analyzed for electrolytes and outcome measures, and data was analyzed.

Detailed Description

Preoperative hyponatremia was identified in patients. The mean change in sodium in hyponatremic patients was compared with inpatients with normal sodium levels. The impact of the delta sodium levels with short-term outcomes, such as duration of intubation, intensive care unit length of stay were analyzed with univariate and multivariate logistic regression analyses.

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2017-12-31
• Study Completion: 2017-12-31
• Study First Submitted: 2019-06-30
• Status Verified: 2019-09
• Study First Submitted QC: 2019-09-29
• Last Update Submitted: 2019-09-29
• Study First Posted: 2019-10-02
• Last Update Posted: 2019-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 342

Inclusion Criteria

• All liver transplant recipients between Jan 2011 to Jan 2017
• Records available

Exclusion Criteria

• Acute fulminant liver failure
• All patients less than 18 years
• Re operated cases
• Pregnant patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Liver Transplant Recipients	Collecting sodium reports and outcome measures	All elective liver transplant recipients done between study period

Primary Outcome Measures

Name	Time	Method
post transplant mortality	1 month	post transplant mortality after liver transplantation
change in serum sodium in liver transplant recipients	1 day	difference between baseline and postoperative sodium in liver transplant recipients

Secondary Outcome Measures

Name	Time	Method
Duration of ICU stay	1 month	Duration of ICU stay after liver transplantation
post operative neurological complications	1 month	Post operative neurological complications after liver transplantation
duration of mechanical ventilation	1 month	duration of mechanical ventilation after liver transplantation
Duration of hospital stay	1 month	Hospital stay after liver transplantation

Trial Locations

Locations (1)

Institute of Liver and Biliary Sciences; 🇮🇳 New Delhi, Delhi, India