Effect of Anesthesia Induction on Cerebral Hemodynamic in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Changes of State Entropy (SE) value during induction
研究概览
简要总结
General anesthesia induces hemodynamic changes, notably a reduction of arterial blood pressure going up to 30%, that may impact cerebral perfusion and oxygenation.The purpose of this study is to assess the impact of anesthesia on the cerebral oxygenation, the perfusion of the brain (assessed with transcranial doppler), and the depth of anesthesia in children between 6 months and 5 years old during the induction of general anesthesia (induced with sevoflurane and/or IV agents). It is expected that the cerebral hemodynamic will be maintained despite systemic variations.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Months 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •General anesthesia for elective surgery
- •American Society of Anesthesiologists score 1 and 2
- •Written informed consent obtained from the parents or legal tutors.
排除标准
- •3 unsuccessful attempts of IV access
- •ultrasound device non available
- •neurologic comorbidity
结局指标
主要结局
Changes of State Entropy (SE) value during induction
时间窗: baseline and 1 minute after intubation
Depth of anesthesia
Changes in NIRS values during induction
时间窗: baseline and 1 minute after intubation
Changes in cerebral Near infra-red spectrometry values
Changes of Response Entropy (RE) value during induction
时间窗: baseline and 1 minute after intubation
Changes in cerebral velocity of the middle cerebral artery during induction
时间窗: baseline and 1 minute after intubation
次要结局
- Changes of arterial blood pressure during induction(At baseline and 1 minute after intubation)
- Endtidal Co2 after induction(1 minute after intubation)
- Changes in NIRS values after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
- Changes of State Entropy (SE) value after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
- Change in cerebral velocity of the middle cerebral artery after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
- Changes of Response Entropy (RE) values after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
研究者
Florent BAUDIN
Principal Investigator
St. Justine's Hospital