Effect of Anesthesia Induction on Cerebral Hemodynamic in Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anesthesia; Reaction
- Sponsor
- St. Justine's Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Changes of State Entropy (SE) value during induction
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
General anesthesia induces hemodynamic changes, notably a reduction of arterial blood pressure going up to 30%, that may impact cerebral perfusion and oxygenation.The purpose of this study is to assess the impact of anesthesia on the cerebral oxygenation, the perfusion of the brain (assessed with transcranial doppler), and the depth of anesthesia in children between 6 months and 5 years old during the induction of general anesthesia (induced with sevoflurane and/or IV agents). It is expected that the cerebral hemodynamic will be maintained despite systemic variations.
Investigators
Florent BAUDIN
Principal Investigator
St. Justine's Hospital
Eligibility Criteria
Inclusion Criteria
- •General anesthesia for elective surgery
- •American Society of Anesthesiologists score 1 and 2
- •Written informed consent obtained from the parents or legal tutors.
Exclusion Criteria
- •3 unsuccessful attempts of IV access
- •ultrasound device non available
- •neurologic comorbidity
Outcomes
Primary Outcomes
Changes of State Entropy (SE) value during induction
Time Frame: baseline and 1 minute after intubation
Depth of anesthesia
Changes in NIRS values during induction
Time Frame: baseline and 1 minute after intubation
Changes in cerebral Near infra-red spectrometry values
Changes of Response Entropy (RE) value during induction
Time Frame: baseline and 1 minute after intubation
Changes in cerebral velocity of the middle cerebral artery during induction
Time Frame: baseline and 1 minute after intubation
Secondary Outcomes
- Changes of arterial blood pressure during induction(At baseline and 1 minute after intubation)
- Endtidal Co2 after induction(1 minute after intubation)
- Changes in NIRS values after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
- Changes of State Entropy (SE) value after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
- Change in cerebral velocity of the middle cerebral artery after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)
- Changes of Response Entropy (RE) values after induction(At 1 minute, 3 minutes after intubation and at the start of surgery)