The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 189
- 试验地点
- 1
- 主要终点
- Change in BMI
研究概览
简要总结
This study assesses the associations between genetic factors, food-cue-related neural reactivity, self-regulatory capacity, eating in the absence of hunger (EAH), and adiposity gain in children.
详细描述
The investigators will assess the associations between genetic factors, food-cue-related neural reactivity, eating in the absence of hunger (EAH) in response to food cues, and adiposity gain in children. They will also determine whether self-regulatory capacity modifies these associations. The genetic factors explored specifically include FTO, MC4R, polymorphisms in genes involved in dopaminergic pathways, and a composite genetic risk score built from genome-wide obesity-related loci.
[3/14/2020]: Study recruitment temporarily halted due to the COVID-19 pandemic
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 8 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •English fluency
- •Willingness to participate in all study visits
排除标准
- •Relevant food allergies or dietary restrictions
- •Metal in or on the body
- •Claustrophobia
- •Psychiatric and neurological disorders
- •Relative in the study
- •Appetite- or attention-altering medications or disorders
研究组 & 干预措施
Food Ads and fMRI
Exposure to food ads during an fMRI scan
干预措施: Food Ads (Behavioral)
Non-Food Ads and fMRI
Exposure to non-food ads during an fMRI scan
干预措施: Non-food Ads (Other)
Food Ads and TV show
Exposure to food ads embedded in an age-appropriate TV program
干预措施: Food Ads (Behavioral)
Non-Food Ads and TV show
Exposure to non-food ads embedded in an age-appropriate TV program
干预措施: Non-food Ads (Other)
结局指标
主要结局
Change in BMI
时间窗: Baseline, 1-year followup
Difference between BMI z-score according to the Center for DiseaSe Control 2000 Growth Reference Curves assessed at baseline and follow-up. Investigators will assess the associations between genetic factors (polymorphisms in FTO, MC4R; and a genetic obesity risk score), food-cue-related neural activity and EAH with change in BMI.
Food-cue-related neural activity
时间窗: Baseline
Activation in brain reward regions in response to food vs. non-food cues, as measured by differences in the blood-oxygen-level dependent response during fMRI scans. Investigators will examine associations between polymorphisms in FTO, MC4R, as well as a genetic risk score with the differential neural activity.
Food-cue-related Eating in the Absence of Hunger (EAH)
时间窗: Baseline, 2 weeks, 4 weeks
Difference in kcals consumed in response to food vs. non-food cue exposure in the behavioral sessions. Investigators will examine how differential neural activity in response to food vs. non-food cues will relate to EAH. Investigators will also assess whether self-regulatory capacity diminishes this association between differential neural activity and EAH.
次要结局
未报告次要终点
研究者
Diane Gilbert-Diamond
Associate Professor
Trustees of Dartmouth College