Effect of Isometric Hand Grip Training on Blood Pressure of Hypertensive Patients With Obstructive Sleep Apnea
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Change at ambulatory blood pressure monitoring
Study Overview
Brief Summary
Obstructive sleep apnea (OSA) is a common clinical condition, involving the development of arterial hypertension. A Meta analysis study have shown that isometric hand grip training promotes blood pressure reduction. It is going to be conducted a clinical trail to determine the effects of hand grip training in OSA patients to change the arterial hypertension.
Detailed Description
Background: obstructive sleep apnea (OSA) is a common clinical condition, involving the development of arterial hypertension. Meta analysis study have shown that isometric hand grip strength promotes blood pressure reduction, and its reduction is higher than that observed after aerobic training. Objective: to analyze the effects of the isometric hand grip on blood pressure changes of patients with uncontrolled arterial hypertension with OSA. Methods: a randomized controlled trial involving 18 adults with OSA and uncontrolled arterial hypertension of both sexes, randomized between control group (receive general guidelines) and hand grip group. 12 weeks of training with load equivalent to 30% of maximum voluntary capacity was performed. All participants will be submitted for evaluation of blood pressure (BP) central and brachial, pulse wave velocity, full polysomnography,before and after the study protocol (the change from the baseline at 12 weeks). Expected results: the authors believe that hand grip training can change (reduce) blood pressure in patient with OSA.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 30 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •OSA diagnose based on polysomnography,
- •Apnea-Hypopnea Index (AHI) > 5,
- •arterial hypertension (systolic arterial pressure > 140 mmHg or diastolic arterial pressure > 90 mmHg)
Exclusion Criteria
- •other heart disease
Arms & Interventions
Control group
Verbal informations about the disease, and exercise behavior, and nutrition.
Intervention: Control (Other)
Hand grip group
Three supervised sessions por week: 4 series (2 at each arm) of two minutes of isometric hand grip contraction at 30% of maximal voluntary contraction. Between series there will be two minutes to rest.
Intervention: Hand grip isometric contraction (Other)
Outcomes
Primary Outcomes
Change at ambulatory blood pressure monitoring
Time Frame: Change from the baseline ambulatory blood pressure monitoring at 12 weeks
24h of monitoring blood pressure
Secondary Outcomes
- Chance at Apnea-Hypopnea Index (AHI)(Change from the baseline AHI at 12 weeks)
- Change at Pulse wave velocity(Change from the baseline pulse wave velocity at 12 weeks)
- Change at blood pressure(Change from the baseline brachial blood pressure at 12 weeks)
Investigators
Rodrigo Pinto Pedrosa
Head of sleep laboratory and heart emergency room of Pernambuco , Principal Investigator.
University of Pernambuco