Prospective randomized clinical trial of accelerated re-epithelialization of split-thickness skin graft donor sites using injectable platelet-rich fibrin (I-PRF)

Phase 2

• Conditions: Epithelialization of split-thickness skin grafting donor site using direct observation method by senior surgeon. The period of complete or excellent healing will be recorded.; Platelet-rich fibrin; Injectable platelet-rich fibrin; Epithelialization; Donor site

• Registration Number: TCTR20240704001
• Lead Sponsor: Buriram Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-04
• Last Update Posted: 19 August 2024
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients who plan to perform split-thickness skin graft procedure

Exclusion Criteria

1. Hematologic disorder
2. Platelet count less than 100,000 per microliter of blood
3. Severe cardiopulmonary disease or septicemia
4. Severe malnutrition
5. Systemic corticosteroid used within 2 weeks before surgery
6. HIV/ AIDS
7. Pregnancy
8. Inflammation or infection of donor site
9. Loss follow-up patients
10. Patients who refuse to participate in the research project

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Healing time Open and clean donor site wound at 7 days, 10 days then every day until complete epithelialization Direct observation by senior surgeon

Secondary Outcome Measures

Name	Time	Method
Epithelial thickness At the day of complete epithelialization Histopathology measurement by pathologist