Serum Copeptin in Cirrhotic Patients With Spontaneous Bacterial Peritonitis

Completed

• Conditions: Spontaneous Bacterial Peritonitis
• Interventions: Diagnostic Test: Serum copeptin

• Registration Number: NCT05401721
• Lead Sponsor: Sohag University

Brief Summary

Current reports have demonstrated that copeptin predicts disease progression and prognosis in cirrhotic patients, independent of liver-specific scoring systems. To the best of our knowledge, few studies have addressed the association between copeptin and sepsis in cirrhotic patients, however, they were performed on different types of infections. Therefore, we will conduct this study with a focus on it is possible role in patients with SBP.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2021-05-01
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-01
• Status Verified: 2022-05
• Study First Submitted: 2022-05-29
• Study First Submitted QC: 2022-05-29
• Last Update Submitted: 2022-05-29
• Study First Posted: 2022-06-02
• Last Update Posted: 2022-06-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

• The diagnosis of liver cirrhosis will be based on clinical data and findings on abdominal ultrasound. The diagnosis of SBP will be based on the presence of at least 250 cells/ml PMNLs in the ascitic fluid, with or without positive ascitic fluid culture in the absence of hemorrhagic ascites and secondary peritonitis

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Exclusion Criteria

• Patients with heart failure, coronary insufficiency, advanced chronic respiratory disease, polyuria-polydipsia syndrome and hypotension or shock.

  • Patients with chronic kidney disease treated with hemodialysis before admission.
  • Patients with previous liver or kidney transplantation.
  • Patients with intraabdominal malignancy.
  • Patients with severe infection other than SBP.
  • Patients who had received antibiotics before hospital admission.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Ascites with SBP	Serum copeptin	Cirrhotic ascitic patients diagnosed with SBP
Ascites without SBP	Serum copeptin	Cirrhotic ascitic patients not diagnosed with SBP

Primary Outcome Measures

Name	Time	Method
compare serum levels of copeptin in cirrhotic patients with and without SBP	6 months	compare serum levels of copeptin in cirrhotic patients with and without SBP

Secondary Outcome Measures

Name	Time	Method
assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function	6 months	assess serum copeptin levels in different stages of cirrhosis and its relationship with kidney and circulatory function

Trial Locations

Locations (1)

Sohag Faculty of Medicine; 🇪🇬 Sohag, Egypt