Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification
- Conditions
- Alcohol; Harmful Use
- Interventions
- Behavioral: Attentional Bias Modification
- Registration Number
- NCT04263259
- Lead Sponsor
- University of New Mexico
- Brief Summary
This study evaluates the efficacy as well as psychological and neurobiological mechanisms of mobile-delivered alcohol attentional bias modification among heavy drinking adults.
- Detailed Description
By testing the efficacy and neurobiological mechanisms of behavior change (MOBC) following attentional bias modification among heavy drinking adults, the proposed study has the potential to unify dual process models and neurobiological models of addiction. The cognitive retraining will be delivered via mobile electronic devices to ensure the cost-effectiveness of these procedures, to allow a large amount of retraining to be delivered in an ecologically valid manner, and to facilitate broad dissemination of such procedures if found to be efficacious. Using an intensive longitudinal experimental design, subjects will be randomly assigned into one of 2 groups (attentional bias modification vs. attentional bias control). Ecological momentary assessment (EMA) data will be used to assess changes in cognitive and behavioral measures in situ, and functional magnetic resonance imaging (fMRI) scans before and after cognitive retraining will be used to examine neural changes in specific regions of interest (ROI).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 31
- Alcohol Use Disorders Identification Test greater than or equal to 8
- right-handed
- history of treatment for or diagnosis of alcohol use disorder/substance use disorder
- history of brain injury
- for females, currently pregnant
- any MRI safety contraindication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Attentional Bias Modification Attentional Bias Modification Participants complete attentional bias modification using a dot probe task on a mobile device up to 5 times per day for a 28-day period (80 trials per assessment).
- Primary Outcome Measures
Name Time Method Alcohol Use Quantity 4 weeks Number of standard drinks per day during the 4-week ecological momentary assessment period
Negative Alcohol-Related Consequences 4 weeks Number negative consequences experienced 4-week ecological momentary assessment period
Alcohol Use Frequency 4 weeks Number of days of alcohol use during the 4-week ecological momentary assessment period
- Secondary Outcome Measures
Name Time Method Alcohol Cue-Induced Neural Reward Circuit Activation 4 weeks Regions of interest include ventral tegmental area, dorsal and ventral striatum
Attentional Bias to Alcohol 4 weeks Measured with the Alcohol Dot Probe Task
Trial Locations
- Locations (2)
Center on Alcoholism, Substance Abuse, & Addictions
🇺🇸Albuquerque, New Mexico, United States
Mind Research Network
🇺🇸Albuquerque, New Mexico, United States