Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

• Conditions: Asthma Acute
• Interventions: Drug: Methylprednisolone,

• Registration Number: NCT06171932
• Lead Sponsor: University of Karachi

Brief Summary

COMPARISON OF EFFICACY OF HYDROCORTISONE AND METHYLPREDNISOLONE IN ACUTE SEVERE ASTHMA

In this study Investigator will compare the efficacy of hydrocortisone and methyl prednisolone in acute severe asthma that will lead to final result and beneficial effects that will help in early resoloution of symptoms and help in preventing recurrence

Detailed Description

investigator will compare the efficacy of hydrocortisone v/s methylprednisolone in management of patients presented with acute severe asthma in emergency.

A local study was conducted in 2009, after that there is a big research gap exists at national level although international literature is available on the same but it can not be generalized to our population due to socio, geographic and economic differences so there is dire need to conduct this study this gives a strong rationale to implement in our settings

Study Timeline

• Study First Submitted: 2023-11-24
• Study Start: 2023-11-26
• Status Verified: 2023-12
• Study First Submitted QC: 2023-12-12
• Last Update Submitted: 2023-12-12
• Study First Posted: 2023-12-15
• Last Update Posted: 2023-12-15
• Primary Completion: 2024-08-01
• Study Completion: 2024-08-08

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Either Gender (18 to 50 years old)
• Patient presenting to emergency department with acute severe asthma

Exclusion Criteria

• Patients with critical illness or pregnant females. .Patient treated other than hydrocortisone and methylprednisolone. .Patients not willing to participate in study.
• Life threatening asthma
• Near fatal asthm

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
METHYLPREDNISOLONE	Methylprednisolone,	Group B will be treated with methylprednisolone 125 mg stat

Primary Outcome Measures

Name	Time	Method
Spirometry	24 hours	Above will be check on arrival of patient to Emergency and post Managment
Blood pressures	24 hours	Vital signs at initial presentation and post managment will be recorded Blood pressure in mm HG will be recorded
Heart rate	24 hours	Heart rate beats/min will be checked
PEAK EXPIRATORY FLOW RATE	24 hours	it wil be checked on arrival and post managment in Peak Expiratory Flow rate (force expiratory volume in 1 second and force vital capacity )will be examined
Respiratory rate	24 hours	Respiratory rate at arrival and post managment will be considered Respiratory rate in Breaths/min

Trial Locations

Locations (4)

Zia ud din hospital university; 🇵🇰 Karachi, Sindh, Pakistan

Zia ud din university hospital; 🇵🇰 Karachi, Sindh, Pakistan

Zia ud din university hospitals; 🇵🇰 Karachi, Sindh, Pakistan

Zia ud din university; 🇵🇰 Karachi, Sindh, Pakistan