Natural Cycle In Vitro Fertilization

Completed

• Conditions: Natural Cycle in Vitro Fertilization (IVF)

• Registration Number: NCT01866618
• Lead Sponsor: Reproductive Medicine Associates of New Jersey

Brief Summary

Natural IVF study patients will undergo an IVF cycle with trigger shots of Lupron \& hCG. Patients will not be given any other stimulating medications during the cycle. They will have 2 uterine aspirations and an endometrial biopsy at designated times. The first uterine aspiration will be randomized to one of four days (day before retrieval, day of retrieval, day after retrieval or 2 days after retrieval). The second uterine aspiration and endometrial biopsy will be performed 6 days after retrieval. Any embryo(s) obtained will be biopsied for Comprehensive Chromosome Screening (CCS) and frozen for use in a subsequent thaw cycle.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-05-20
• Study First Submitted QC: 2013-05-28
• Study First Posted: 2013-05-31
• Primary Completion: 2016-08
• Study Completion: 2016-12
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-05
• Last Update Posted: 2018-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 524

Inclusion Criteria

• Ovulatory cycles every 39 days or less (natural cycle IVF cannot be performed in someone who does not have cycles)
• Must be RMANJ patient and have completed all diagnostic screening at one of our RMANJ locations. All diagnostic screening is NOT covered under the study and must be completed prior to being allowed to start the study cycle.

Exclusion Criteria

• Prior enrollment/attempt in this study
• Requirement for surgical sperm extraction
• Inability to assess ovaries via transvaginal ultrasound
• Inability to tolerate vaginal examination

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endometrial Changes	1 Year	To examine the endometrium within the natural cycle in order to accurately characterize the differences in multiple aspects of endocrine and paracrine hormonal activity, the transcriptome of cells influencing oocyte maturation and changes in the endometrium.

Secondary Outcome Measures

Name	Time	Method
Aneuploidy Rates	1 Year	To examine aneuploidy rates in embryos from natural IVF cycles.

Trial Locations

Locations (1)

Reproductive Medicine Associates of New Jersey; 🇺🇸 Basking Ridge, New Jersey, United States