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Clinical Trials/EUCTR2005-004398-76-GB
EUCTR2005-004398-76-GB
Active, not recruiting
Not Applicable

A comparison of Myocardial Protection Using Preconditioning with Sevoflurane Against High Thoracic Epidural Analgesia for CABG Surgery

Golden Jubilee National Hospital0 sites150 target enrollmentFebruary 20, 2006
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DrugsSevofluraneChirocaine

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
Golden Jubilee National Hospital
Enrollment
150
Status
Active, not recruiting
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
February 20, 2006
End Date
TBD
Last Updated
14 years ago
Study Type
Interventional clinical trial of medicinal product
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Patients presenting for elective CABG operations, with \>40 % left ventricular ejection fraction, aged 40\-80\.
  • •Are the trial subjects under 18? no
  • •Number of subjects for this age range:
  • •F.1\.2 Adults (18\-64 years) yes
  • •F.1\.2\.1 Number of subjects for this age range
  • •F.1\.3 Elderly (\>\=65 years) yes
  • •F.1\.3\.1 Number of subjects for this age range

Exclusion Criteria

  • •Patients at risk of epidural haematomas (i.e. platelets \<100, coagulopathies, on anticoagulant therapies, INR\>1\.4\) or unsuited to HTEA (patient refusal, spinal deformities).
  • •Patients on drugs shown to manipulate the preconditioning phenomenon will also be excluded. This includes those on diazoxide, nicorandil, oral sulfonylureas and theophyllines.
  • •Patients with preoperative ECG morphologies likely to make interpretation difficult or impossible including: left bundle branch block, cardiac pacemaker dependence.
  • •Haemodynamically compromised patients requiring inotropic or balloon pump support preoperatively.
  • •Significant valvular disease.
  • •Preoperative elevated levels of troponin I or CKMB.
  • •Unstable angina or angina in 24 hours preop.

Outcomes

Primary Outcomes

Not specified

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