Efficacy of individualised homoeopathic medicines in the treatment of premenstrual syndrome assessed by premenstrual syndrome scale (PMSS) -a quasi-experimental time series design.

This quasi-experimental time-series study evaluates the efficacy of individualized homeopathic medicines in treating Premenstrual Syndrome (PMS) among 55 women aged 18-40, diagnosed using ACOG criteria. The study employs a two-phase design: a 3-month placebo phase with monthly Premenstrual Syndrome Scale (PMSS) assessments followed by a 3-month active treatment phase with individualized homeopathic remedies. The primary outcome measures the change in total PMSS scores from baseline to treatment completion, assessing overall symptom severity reduction. The study focuses on core PMS symptoms across physiological, psychological, and behavioral domains while excluding participants on hormonal or psychiatric medications. This design provides longitudinal data on homeopathic treatment effects while maintaining clinical practicality in a real-world setting.