ACTRN12610000522011
Completed
未知
A randomised, controlled crossover trial of the effect of high concentration oxygen on transcutaneous carbon dioxide tension in obese hospitalised patients.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Hypercapnia as a consequence of oxygen therapy in obese individuals.
- Sponsor
- Medical Research Institute of New Zealand
- Enrollment
- 48
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Current internal medicine inpatient in Wellington Hospital; 2\. Age \>/\= 16 years; 3\. Body Mass Index (BMI) \> 40kg/m2\.
Exclusion Criteria
- •1\. Diagnosis of Chronic Obstructive Pulmonary Disease (COPD); 2\. Ratio of Forced Expiratory Volume in one second to Forced Vital Capacity (FEV1:FVC) \< 0\.7 (First 24 participants recruited only); 3\. Patients currently receiving treatment with Continuous Positive Airway Pressure (CPAP) ventilation or Non\-Invasive Positive Pressure Ventilation (NIPPV); 4\. Patients currently requiring \>2L/minute of oxygen therapy following titration to the recommended target saturation range of 88\-92% (First 24 participants recruited only); 5\. Patients with baseline PtCO2 of \>65mmHg; 6\. Current diagnosis of disease causing restriction to chest wall expansion, other than obesity i.e. neuromuscular disease or chest wall dysfunction; 7\. Administration of respiratory suppressant medications, including opiate analgesia and benzodiazepines within 24 hours (First 24 participants recruited only); 8\. Patients with unstable angina or recent myocardial infarction.
Outcomes
Primary Outcomes
Not specified
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