Can the antibiotic Doxycycline help control the complications (dyskinesias) of levodopa treatment in patients with Parkinson's Disease?

Phase 1

• Conditions: Drug induced chorea

• Registration Number: RBR-1047fwbf
• Lead Sponsor: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-05-12
• Study Completion: 2022-05-30
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients 18 years of age or older; diagnosed with Parkinson's disease according to the United Kingdon Parkinson's Disease Society Brain Bank clinical diagnostic criteria; presenting at the initial evaluation with at least some functional impact dyskinesias (score higer than1 on item 4. 2 of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS); who are using levodopa at least three times a day; and who can keep doses of antiparkinsonian medications unchanged for at least four weeks prior to screening and during study participation.

Exclusion Criteria

Diagnosis of atypical or secondary parkinsonism; treatment of any experimental drug or other intervention within 90 days prior to screening or baseline assessment; presence of moderate or severe psychotic symptoms (score greater than 2 on item 1. 2 of the Movement Disorders Society's Unified Scale for Assessment of Parkinson`s disease; diagnosis of dementia according to the Movement Disorders Society diagnostic criteria; suffering from serious systemic conditions (infections, malignancies, chronic kidney or liver disease); pregnancy or lactation; history of hypersensitivity or allergic reaction to tetracyclines; absence of clinical dyskinetic movements at baseline assessment.

Study & Design

• Study Type: Intervention
• Study Design: Not specified