DRKS00015682已完成3 期
Analysis of extracellular vesicles and circulating microRNAs in remote ischemic preconditioning of coronary artery disease patients dependent on anesthetic regime - ExoRIP
Ruhr-Universität Bochum Marienhospital HerneKlinik für Anästhesiologie, operative Intensivmedizin,Schmerz- und Palliativmedizin0 个研究点目标入组 65 人开始时间: 2018年12月20日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 65
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized controlled study
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 45 Years 至 85 Years（—）
- 性别
- All
入选标准
- •Coronary heart disease
- •CABG (Coronary artery bypass graft) surgery with cardiopulmonary bypass
- •ages 45 to 85 years
- •Antegrade Bretschneider cardioplegia
- •Mild hypothermia (32C °)
- •Preoperative standard medication (statins, beta-blockers, aspirin)
- •Standard anesthesia (isoflurane, sufentanil)
- •Intraoperative standard protocol (full heparinization with ACT> 400s, aprotinin, protamine)
- •Postoperative standard protocol (500mg aspirin after 2 hours, Low-dose heparinization after 4h)
排除标准
- •Condition after acute myocardial infarction
- •combined valvular
- •Emergency operation
- •catecholamine
- •Unstable angina
- •IABP mounting
- •pre- / intraoperative use of phosphodiesterase inhibitors
- •reoperation
- •COPD GOLD III and IV
- •renal insufficiency with creatinine> 1.5 mg / dl
- •Dual antithrombotic therapy (clopidogrel + aspirin)
- •Repeated cardiopulmonary bypass
- •Repeated cross clamping of the aorta
- •Intraoperative complications (bypass low-flow / -lock, frustrane valve reconstruction, Klappenausriss, aortic dissection, pump failure, implantation of cardiac assist systems)
- •aortic cross clamping> 150 min
- •Moderate / deep hypothermia (<32C °)
- •Antithrombotic therapy (intraoperatively clopidogrel u. / O. Aspirin)
- •Retrograde cardioplegia delivery
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