NCT04562311进行中（未招募）2 期
The Efficacy and Safety of Chidamide Combined With Immunotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Who Had Previously Received Platinum-based Chemotherapy:An Open, One-arm, Phase II Study
Sun Yat-sen University1 个研究点 分布在 1 个国家目标入组 45 人开始时间: 2021年1月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Objective Response Rate（ORR）
研究概览
简要总结
Study of Chidamide Combined With Immunotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Who Had Previously Received Platinum-based Chemotherapy
详细描述
Chidamide has been approved for the treatment of relapsed or refractory peripheral T-cell lymphoma in China (Chidamide,a novel histone deacetylase inhibitor). Tirelizumab,has been approved for the failure treatment of platinum-containing chemotherapy with high PD-L1 expression included locally advanced or metastatic Urothelial carcinoma in China(Tirelizumab,BGB-A317 is an investigational humanized IgG4 anti-PD-1 monoclonal antibody ).The aim of this study was to observe the efficacy and safety of Chidamide with Immunotherapy in patients with progression of platinum-based chemotherapy recurrent and metastatic Urothelial carcinoma.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1.Age ≥18 years, < 75 years
- •2.Histopathological diagnosis of transitional cell carcinoma or urothelial carcinoma; It may be associated with other cell types such as small cell carcinoma, neuroendocrine carcinoma or squamous cell carcinoma, but the component should be mainly urothelial carcinoma
- •3.Patients with advanced urothelial carcinoma (inoperable or metastatic to lymph nodes or distant metastases) recurred or progressed during adjuvant therapy or advanced first-line platinum-based chemotherapy; Patients receiving secondary chemotherapy may be included, but more than 12 months from the end of the first chemotherapy to the beginning of the second chemotherapy; Subjects who receive neoadjuvant chemotherapy or adjuvant chemotherapy and who develop disease progression within 12 months of the last dose are considered to be receiving systemic chemotherapy in the context of cancer metastasis (disease progression is defined as any progression requiring a change in treatment regimen prior to treatment)
- •4.Measurable target lesion (without radiotherapy) : defined as having at least one lesion that can be accurately measured in at least one dimension (the longest diameter recorded), such as ≥15mm conventional technique or ≥10mm helical CT scan; Patients with bone metastases may also participate in the study, provided they also have a measurable non-osseous disease
- •5.Life expectancy is more than 3 months
- •6.ECOG performance status 0~2 (Karnofsky >= 60%)
- •7.Bone marrow, liver and renal function adequate: Blood routine examination: neutrophil count ≥2.0×109/L, PLT count ≥75×109/L, WBC count ≥3.0×109/L, hemoglobin concentration ≥90.0g/dL; Liver function: AST and ALT≤1.5 times the upper limit of normal value (ULN), alkaline phosphatase ≤1.5×ULN, TBIL≤ULN; Cr 1.5 x ULN or less
- •8.Left ejection fraction (LVEF) ≥50%, electrocardiogram (ECG) was generally normal, QTc interphase <0.44 seconds, and there were no signs or symptoms of heart failure
- •Acute toxicity caused by previous treatment is alleviated to level ≤1 (except hair loss)
- •10.The eligibility of patients receiving any drug or substance known or likely to affect cedaramide activity or pharmacokinetics will be determined after review by the principal investigator for a period of more than 6 weeks
- •11.Understand and be willing to sign written informed consent documents
排除标准
- •1.Patients who received chemotherapy (nitrosourea or mitomycin C for 6 weeks) within 4 weeks before the study began, or who did not recover from adverse events due to drug use more than 4 weeks in advance
- •2.Patients shall not receive any other anticancer drugs or clinical trial drugs during the clinical trial period (local palliative radiotherapy other than the target lesion may be accepted)
- •3.Patients with brain metastases
- •4.A history of allergic reactions to compounds that are chemically or biologically similar to cedarbenamine; These compounds include sodium butyrate, Trichostatin A (TSA), Trapoxin (TPX), MS-27-275, and Depsipeptide
- •5.Treatment of Urothelial carcinoma with more than two lines or above cytotoxic chemotherapy regiments
- •6.Uncontrolled underlying concomitant diseases, including but not limited to persistent or active infections, symptomatic congestive heart failure, unstable angina, arrhythmia, or psychiatric/social conditions, may limit compliance with study requirements
- •7.Pregnant women are excluded and should stop breastfeeding if they receive treatment during lactation in the study
- •8.Long-term use of immunosuppressive agents after organ transplantation; Patients with autoimmune diseases; Patients who are taking immunosuppressive drugs
- •9.HIV positive or have other immunodeficiency diseases
- •10.Combined with other active malignancies (i.e., changes in treatment required within the past 24 months). Only patients with skin cancer that has been treated within the past 24 months and has been completely cured are allowed to be enrolled. Localized prostate cancer with Gleason score of 6 (treated or untreated but monitored within the past 24 months); Localized prostate cancer with a Gleason score of 3+4 that was treated more than 12 months prior to full study screening and was completely cured
- •11.Live virus vaccine is administered within 30 days of initial administration
- •12.Patients should not take valproic acid for at least 2 weeks before entering the study
- •13.Due to psychological, social, family, geographical and other reasons can not cooperate with regular follow-up observers
研究组 & 干预措施
Chidamide with Immunotherapy
Experimental
Chidamide: 30mg orally BIW. Immunotherapy: tislelizumab,the fixed dose of 200 mg IV. Treatment cycles are repeated every 3 weeks.
干预措施: Chidamide (Drug)
结局指标
主要结局
Objective Response Rate（ORR）
时间窗: up to 2 years
Objective Response Rate（ORR）by RECIST 1.1,the total proportion of patients with complete response（CR）, partial response（PR）
次要结局
- Disease Control Rate （DCR）(up to 2 years)
- Progression-free survival(PFS)(up to 2 years)
- Overall survival(OS)(up to 2 years)
研究者
ZHOU FANGJIAN
Head of UrologyDepartment,Sun Yat-sen University Cancer center
Sun Yat-sen University
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Chidamide Combined With Zimberelimab in the Treatment of Metastatic Triple-negative Breast Cancer PatientsTriple Negative Breast CancerNCT05632848Sun Yat-sen University47
Unknown
2 期
Chidamide With PET Regimen for Angioimmunoblastic T Cell Lymphoma (PET: Prednisone, Etoposide and Thalidomide)Angioimmunoblastic T-cell LymphomaNCT03273452Qingdao University30
尚未招募
2 期
A Prospective, Randomized, Open, Phase II Clinical Study of Chidamide in Combination with Camrelizumab and Apatinib for Advanced Esophageal CancerAdvanced Esophageal CarcinomaNCT06745193Peking University63
Unknown
2 期
A Phase II Trail of Chidamide ,Rituximab and Methotrexate in Lymphoma PatientsCentral Nervous System LymphomaNCT04516655Fudan University51
Unknown
2 期
Chidamide Combined With VDDT Regimen in the Relapse and Refractory Diffuse Large B Cell LymphomaDiffuse Large B-cell LymphomaNCT02733380Henan Cancer Hospital20