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Clinical Trials/NCT06119802
NCT06119802RecruitingNot Applicable

Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial Fibrillation

Yinglong Hou1 site in 1 country10,000 target enrollmentStarted: January 1, 2022Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Recruiting
Sponsor
Enrollment
10,000
Locations
1
Primary Endpoint
Uric acid/SOD ratio is associated with atrial fibrillation

Study Overview

Brief Summary

To clarify the predictive effects of uric acid and superoxide dismutase as biomarkers of oxidative stress on atrial fibrillation, and to provide greater value for the diagnosis and prediction of atrial fibrillation. It provides a new idea for the prevention and treatment of atrial fibrillation.

Detailed Description

In recent years, a growing number of reports have shown the importance of oxidative stress in the pathophysiological mechanism of AF. During oxidative stress, there is an imbalance between the production of pro-oxidant reactive species and the antioxidant defenses of the cell, and excessive oxidation leads to oxidative damage and cell death. Redox processes can lead to atrial fibrosis and cardiac remodeling , suggesting that strategies to address myocardial oxidative stress may constitute a reasonable approach for the treatment of AF. However, few studies have reported the relationship between comprehensive oxidative stress-related biomarkers and AF. The purpose of this study was to illuminate the relationship of several blood markers of oxidative stress with AF and to provide new clues for the prevention and treatment of AF.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to 90 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • This retrospective study enrolled all hospitalized patients from January 2018 to December 2020 at the Department of Cardiology in The First Affiliated Hospital of Shandong First Medical University. The diagnosis of AF was based on 12-lead electrocardiography (ECG) or 24-hour Holter monitoring, and classification was based on the published 2020 ESC guidelines for the diagnosis and management of AF.

Exclusion Criteria

  • acute heart failure and acute myocardial infarction;
  • severe liver or kidney dysfunction (with aspartate aminotransferase or alanine aminotransferase levels three times higher than normal and estimated glomerular filtration rate <30 ml/ (min*1.73 m2));
  • malignant tumors;
  • missing data of laboratory indicators at baseline.

Outcomes

Primary Outcomes

Uric acid/SOD ratio is associated with atrial fibrillation

Time Frame: 3 years

Uric acid/SOD ratio is associated with atrial fibrillation

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Yinglong Hou
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Yinglong Hou

professor

Qianfoshan Hospital

Study Sites (1)

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