Efficacy of alternative dressing and securement options for peripherally inserted central catheters (PICCs) in the prevention of PICC failure and infection. the PISCES Trial

Not Applicable

Completed

• Conditions: Public Health - Health service research; Peripherally inserted central catheter (PICC) failure; Catheter-associated bloodstream infection (CABSI); Infection - Studies of infection and infectious agents; Cancer - Any cancer

• Registration Number: ACTRN12616000315415
• Lead Sponsor: Griffith University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-10
• Study Completion: 2020-10-29
• Last Update Posted: 14 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1027

Inclusion Criteria

1. Cancer patient (haematological malignancy or solid tumour)
2. PICC scheduled/expected use >24 hours
3. Informed written consent

To ensure generalisability, PICCs inserted after-hours will also be studied if the following additional inclusion criteria are met:
4. <24 hours since PICC insertion
5. The treating clinician agree it is safe to replace the initial dressing/securement.

Exclusion Criteria

1. Other CVC insertion (not PICC)
2. Current bloodstream infection (<48 hours)
3. PICC inserted through burned or diseased skin
4. Known allergy to any study product
5. Non-English speaking patients without interpreter
6, CHG disc/dressing already in place.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dressing Hypothesis: Catheter-associated bloodstream infection, as defined by CDC NHSN criteria. This will be confirmed by a blinded infectious diseases specialist using de-identified clinical and microbiological data. [48 hours after device removal, or patient removal from study (8 week after device insertion).];Securement Hypothesis: Peripherally inserted central catheter (PICC) failure (composite measure of any reason for unplanned PICC removal, including infection, occlusion, dislodgement and venous thrombosis). This outcome will be assessed by a review of patient medical records.[At time of PICC removal or patient removal from study (8 week after device insertion).]