Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols

Recruiting

• Conditions: Healthy

• Registration Number: NCT01728597
• Lead Sponsor: Medical University of Graz

Brief Summary

One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is well known that the diagnostic impact of cardiac MR investigations crucially depends on the adaption of imaging protocols to patients' state and ability to cooperate.

The aim of the present study is the evaluation and optimization of various 1.5 Tesla and 3 Tesla cardiac MR investigation protocols without application of contrast agent as well as the acquisition of normal values for new cardiac MR images techniques:

* normal myocardial morphology: T1-, T2- and T2\*-weighted imaging and acquisition of normal values of magnetic relaxation times (sequence- and protocol dependent),

* normal cardiac function: systolic and diastolic function (sequence- and protocol dependent),

* cardiac anatomy and coronary artery imaging: feasibility to evaluate length, diameter and blood flow (sequence- and protocol dependent),

* normal blood flow topologies in the heart and the surrounding great vessels: 2D- and 3D blood flow imaging and evaluation techniques (sequence- and protocol dependent).

Detailed Description

Not available

Study Timeline

• Study Start: 2011-12
• Study First Submitted: 2012-11-03
• Study First Submitted QC: 2012-11-13
• Study First Posted: 2012-11-20
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-10
• Last Update Posted: 2025-02-12
• Primary Completion: 2025-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• No history of cardiac or pulmonary diseases
• ability to give informed consent

Exclusion Criteria

• General MR exclusion criteria eg. patients with metal devices or other magnetic material in or on the subjects body which will be hazardous for MR investigation (e.g. heart pace-maker, brain aneurysm clip, nerve stimulators, electrodes, penile implants, coloured contact lenses, patch to deliver medications through the skin, any metal implants as rods, joints, plates, pins, screws, nails or clips, embolization coil, or any metal fragments or shrapnel in the body),
• pregnancy,
• claustrophobia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cardiac performance	up to 1 week	ejection fraction of cardiac chambers \[%\], sequence- and protocol dependent
coronary artery anatomy	up to 1 week	length and diameter \[mm\], sequence-, and protocol dependent
blood flow vorticity	up to 1 week	number of vortices of blood flow in the heart and surrounding great vessels, sequence and protocol dependent
blood flow timing	up to 1 week	time points of characteristic blood flow patterns in the heart and surrounding great vessels in the cardiac cycle \[ms\], sequence-, and protocol dependent
cardiac muscle mass	up to 1 week	systolic and end-diastolic mass of cardiac chambers \[g\], sequence- and protocol dependent
cardiac volumes	up to 1 week	volumes of cardiac chambers in the cardiac cycle \[ml\], sequence- and protocol dependent
magnetic relaxation times	up to 1 week	systolic and diastolic T1, T2, T2\* \[ms\], sequence- and protocol dependent
blood flow velocity	up to 1 week	maximum, minimum and average velocity \[cm/s\], sequence-, and protocol dependent

Trial Locations

Locations (1)

Medical Unitersity Graz, Department of Radiology, Division of General Radiology; 🇦🇹 Graz, Styria, Austria