A Comparison of Hearing Level between Before and After Intratympanic Dexamethasone Injection in Patient with Sudden Sensorineural Hearing Loss after Failure of Oral Prednisolone Therapy

Phase 3

Completed

• Conditions: Intratympanic Dexamethasone Injection in Patient with Sudden Sensorineural Hearing Loss after Failure of Oral Prednisolone Therapy; Idiopathic sudden sensorineural hearing loss; Intratympanic dexamethasone injection; ineffective oral prednisolone

• Registration Number: TCTR20220128003
• Lead Sponsor: Chaophrayayommarat Hospital Ethical Committee

Brief Summary

Conclusions : Intratympanic dexamethasone injection in a group of patients with sudden sensorineural hearing loss unresponsive to oral prednisolone resulted in a statistically significant improvement in the hearing level.

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-01-20
• Study Start: 2022-01-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Over 18 years of age, having a hearing level greater than 30 decibels over 3 consecutive frequencies. by the time since the disease until less than 4 weeks, did not respond to treatment with oral prednisolone

Exclusion Criteria

Otitis, eardrum perforation, ear infection, history of head injury, history of surgery or an ear accident or have had radiation to the head and neck, received steroids by mouth or injection within 1 month before diagnosis, allergic to steroids or anesthetics, water in the ear, History of meningitis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pure tone Audiogram level 1 month Decibel

Secondary Outcome Measures

Name	Time	Method
Speech discrimination score 1 month percent