Parathyroid Adenoma Detection With Rubidium Chloride Imaging: A Proof-of-Concept Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Uptake pattern of rubidium-82 in parathyroid adenomas
研究概览
简要总结
Assess the uptake of rubidium-82 in parathyroid adenomas.
详细描述
Parathyroid adenomas demonstrate uptake of rubidium-82 chloride and can be detected with PET imaging.
The investigators aim to describe the uptake pattern of rubidium-82 chloride in parathyroid adenomas as well as compare the uptake pattern of rubidium-82 chloride to that of 18F-fluorocholine in patients with parathyroid adenoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ability to undergo imaging logistics
- •Ability to provide informed consent
- •Biochemical evidence of primary hyperparathyroidism
- •Documented parathyroid adenoma on prior 18F-fluorocholine imaging
排除标准
- •Normocalcemic primary hyperparathyroidism
- •Breastfeeding or pregnancy
- •Claustrophobia or inability to undergo imaging logistics
- •Any other history, condition, therapy, or uncontrolled intercurrent illness, which could in the opinion of the investigator affect compliance with study requirements or which would make the participant unsuitable for this study
结局指标
主要结局
Uptake pattern of rubidium-82 in parathyroid adenomas
时间窗: 3 months
Rudibium-82 uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values.
次要结局
- Comparison between the uptakes of rubidium-82 and 18F-fluorocholine in patients with parathyroid adenomas(3 months)
研究者
Matthieu Pelletier-Galarneau, MD MSc
Chief of the Nuclear Medicine Department
Montreal Heart Institute