Sarcopenia Measured by Ultrasound in Hospitalized Older Adults

Completed

• Conditions: Sarcopenia

• Registration Number: NCT05113758
• Lead Sponsor: Pedro Abizanda

Brief Summary

Observational prospective study in older adults admitted to an Acute Geriatric Unit, in which sarcopenia will be evaluated by ultrasound in the anterior rectus femoris muscle.

Detailed Description

The main objective of the study is to estimate, by means of portable ultrasound, parameters of muscle quantity and quality (anterior rectus femoris muscle area, width and echostructure ) in older adults hospitalized in Acute Geriatric Units for medical reasons.

Study Timeline

• Study Start: 2019-05-28
• Study First Submitted: 2021-10-29
• Study First Submitted QC: 2021-10-29
• Study First Posted: 2021-11-09
• Primary Completion: 2022-06-30
• Study Completion: 2022-06-30
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-29
• Last Update Posted: 2023-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 161

Inclusion Criteria

• Patients over 69 years of age.
• Hospitalization for a medical cause in Acute Geriatric Units.
• Holden's Functional Ambulation Classification Scale at level 1 or higher.
• Informed consent signed by the patient or legal representative.

Exclusion Criteria

• Terminal condition or life expectancy of less than 6 months.
• Impossibility or refusal to undergo muscle ultrasound.
• Refusal for follow-up
• Severe dementia stage Global Deteriorating Scale: 7
• Impossibility in the opinion of the investigators to complete the necessary data for the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle mass (the anterior rectus femoris muscle)	15 days	The evolution of muscle mass between admission and discharge will be assessed by ultrasound
Prevalence of sarcopenia on admission	72 hours	Prevalence of sarcopenia on admission. A prevalent case of sarcopenia will be considered if a patient fulfills the EWGSOP2 at admission
Incidence of sarcopenia between admission and discharge	15 days	An incident case of sarcopenia will be considered if a patient not fulfilling EWGSOP2 diagnostic criteria on admission, will meet diagnostic criteria at discharge of sarcopenia at discharge (diagnosis will be considered as a dichotomous variable -yes/no-).

Secondary Outcome Measures

Name	Time	Method
Length of stay, days	15 days	Day of admission to day of discharge
Minimal nutritional assessment (MNA-SF) score	72 hours	The mini-nutritional assessment - short form is a simple, non - invasive and validated scale for the detection of malnutrition in older adults. It takes into account the patient's loss of appetite, weight loss, motor skills, recent health status, neuropsychological disorders. The maximum score of the MNA-SF is 14: Greater than or equal to 11: normal nutritional status. Between 8 and 11: risk of malnutrition. Less than 8: malnutrition.
4-meter walking speed test	15 days	The evolution of the value of the 4-meter walking speed test between admission and discharge will be assessed.
SPPB score (SHORT PHYSICAL PERFORMANCE BATTERY score)	15 days	Short Physical Performance Battery (SPPB): score range 0-12, higher score means a better outcome
Mortality	3 months	Mortality will be measured with vital status at 3 months.
Emergency department (ED) visit(s)	3 months	ED visit(s) after index hospitalization, Dichotomous outcome (yes/no)
ADL (Activities of Daily Living) questionnaire	3 months	the ADL questionnaire will also be performed on admission, at discharge, and at 3 months.
Hand grip strength	15 days	Using a hand-held dynamometer
Readmission(s) after index hospitalization	3 months	Readmission(s) after index hospitalization, Dichotomous outcome (yes/no)

Trial Locations

Locations (1)

Complejo Hospitalario Universitario de Albacete; 🇪🇸 Albacete, Spain