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Clinical Trials/NCT06209541
NCT06209541
Active, not recruiting
Not Applicable

Tailored or Transdiagnostic ICBT with a Specific Therapist or Team Support: a Factorial Randomized Controlled Trial

Linkoeping University2 sites in 1 country176 target enrollmentJanuary 8, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Depression Symptoms
Sponsor
Linkoeping University
Enrollment
176
Locations
2
Primary Endpoint
Beck Anxiety Inventory
Status
Active, not recruiting
Last Updated
last year

Overview

Brief Summary

The purpose of this study is to investigate the differences in treatment outcomes between individually tailored and transdiagnostic internet-based cognitive behavioral therapy (ICBT), as well as the differences between weekly support by a specific therapist and weekly support by a team. The target group is adults (18 years or older) who experience mild to moderate depression symptoms, anxiety, stress or other psychological symptoms. The ICBT, in both types of treatment contents, consists of modules that the participants will work with for eight weeks in total. Participants will be recruited in Sweden with nationwide recruitment.

Detailed Description

This study is a factorial randomized controlled trial with the aim to investigate ICBT with two kinds of treatment contents and two kinds of support. Participants will either be randomized to an individually tailored treatment, where they will be selecting their own modules that they wish to work with, or be randomized to a transdiagnostic treatment, that consists of Unified Protocol that is developed by David Barlow and colleagues. Participants will also be randomized to either get weekly support by one specific therapist or get support by "a team", meaning that the participant will get support from different therapists each week. In both kinds of support, the participant will have the opportunity to ask for support during the other times of the week as well. Primary outcome measures are depression symptoms (measured with Beck Depression Inventory-II) and anxiety symptoms (measured with Beck Anxiety Inventory). Other, secondary, outcome measures used will for example be about stress symptoms, insomnia symptoms, and quality of life. Pre-treatment measurement, post-treatment measurement and one-year follow up is planned to be collected through an online survey.

Registry
clinicaltrials.gov
Start Date
January 8, 2024
End Date
April 30, 2026
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Linkoeping University
Responsible Party
Principal Investigator
Principal Investigator

Gerhard Andersson

Professor

Linkoeping University

Eligibility Criteria

Inclusion Criteria

  • Experience mild to moderate psychological symptoms or problems
  • 18 years or older
  • Ability to speak, read and write in Swedish
  • Have access to the internet and a smartphone, computer or other device

Exclusion Criteria

  • Severe psychiatric or somatic illness that makes participation harder or impossible
  • Ongoing addiction
  • Acute suicidality
  • Other ongoing psychological treatment
  • Recent (within the latest month) changes in the dose of psychotropic medication or planned change of dose during the treatment weeks

Outcomes

Primary Outcomes

Beck Anxiety Inventory

Time Frame: Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.

Measure of anxiety symptoms, consisting of 21 items. Range for the total sum is between 0 and 63, interpreted as minimal anxiety (0-7), mild anxiety (8-15), moderate anxiety (16-25) and severe anxiety (26-63).

Becks Depression Inventory-II

Time Frame: Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.

Measure of depressive symptoms. Range for the total sum is between 0 and 63 with a higher score indicating a higher level of depressive symptoms. Clinical ranges for minimal, mild, moderate and severe major depressive disorder are considered to be 0-13, 13-19, 20-28, and 29-63 points respectively.

Secondary Outcomes

  • Rosenberg's Self-esteem Scale(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • Perceived Stress Scale-14(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • Brunnsviken Brief Quality of Life Scale(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • Patient Health Questionnaire-15(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • Insomnia Severity Index(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • Alcohol Use Disorder Identification Test(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • Goldberg's (1999) IPIP representation of Costa McCrae's (1992) NEO-PI-R Domains(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)
  • InCharge Financial Distress/Financial Well-Being Scale(Change between baseline, end of treatment after eight weeks and follow-up at 12 months after treatment termination.)

Study Sites (2)

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