oninvasive tumor detection by sensitive profiling of circulating tumor DNA in saliva

Recruiting

• Conditions: C00-C97; Malignant neoplasms

• Registration Number: DRKS00019849
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients:
- tumor activity
- known tumor mutation
- presence of blood plasma and saliva in the Freiburg Biobank

healthy subjects:
- minimum 18 years old
- ready to donate two saliva samples and to have peripheral blood drawn (36ml)

Exclusion Criteria

Healthy subjects:
- pre-existing chronic disease, especially cancer or rheumatological diseases
- pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Detection rate of ctDNA from saliva<br>2. Correlation of ctDNA levels between saliva and blood plasma

Secondary Outcome Measures

Name	Time	Method
1. Detection rate of ctDNA from saliva collected with a buccals swab or with NaCl solution